Warrell R P, Hultin M B, Coller B S
Am J Med. 1979 Feb;66(2):226-8. doi: 10.1016/0002-9343(79)90531-x.
Factor VIII/von Willebrand factor antigen and von Willebrand factor activity (ristocetin assay) were studied in 12 patients in renal failure. A dramatic increase in both activities was observed (antigen 315 +/- 30 per cent in patients verus 104 +/- 9 per cent in control subjects; activity 402 +/- 48 per cent in patients versus 111 +/- 5 per cent in control subjects; p less than 0.001 for both). Since von Willebrand factor is thought to play at least a facilitative role in the development of arteriosclerosis, these increased activities may contribute to the premature arteriosclerosis reported in patients with chronic renal failure undergoing dialysis.
对12例肾衰竭患者的凝血因子VIII/血管性血友病因子抗原和血管性血友病因子活性（瑞斯托霉素检测）进行了研究。观察到这两种活性均显著增加（患者抗原为315±30%，而对照受试者为104±9%；患者活性为402±48%，对照受试者为111±5%；两者p均小于0.001）。由于血管性血友病因子被认为至少在动脉硬化发展中起促进作用，这些增加的活性可能导致接受透析的慢性肾衰竭患者中报道的过早动脉硬化。
