Department of Obstetrics and Gynaecology, Juntendo University Faculty of Medicine, Tokyo, Japan.
Department of Obstetrics and Gynaecology, Juntendo University Faculty of Medicine, Tokyo, Japan; Centre for Reproductive Medicine and Implantation Research, Sugiyama Clinic Shinjuku, Tokyo, Japan.
Reprod Biomed Online. 2019 Aug;39(2):205-210. doi: 10.1016/j.rbmo.2019.03.205. Epub 2019 Mar 20.
Does resveratrol, a polyphenolic compound, affect IVF-embryo transfer outcomes?
This single-centre, cross-sectional retrospective study was designed to compare the outcomes of embryo transfer cycles in women receiving resveratrol supplementation (200 mg/day) continuously (RES group) with a control group (non-RES group). Of 8686 embryo transfer cycles, 1409 cycles with poor prognostic factors were excluded, including cycles in women aged ≥43 years and those with poor-quality embryos. The RES group (204 cycles, 102 women) was compared with the non-RES group (7073 cycles, 2958 women).
After matching patients by age at the time of oocyte retrieval, grade and developmental stage of embryos, number of embryos transferred, and fresh or vitrified-warmed embryo transfer, multivariate logistic regression analysis showed that resveratrol supplementation is strongly associated with a decrease in clinical pregnancy rate [odds ratio (OR) 0.539, 95% confidence interval (CI) 0.341-0.853] and an increased risk of miscarriage (OR 2.602, 95% CI 1.070-6.325).
Resveratrol supplementation during embryo transfer cycles appears to be detrimental for pregnancy outcomes. An analysis of the supplementation protocol and randomized controlled studies are needed.
白藜芦醇，一种多酚化合物，是否会影响试管婴儿胚胎移植的结果？
这项单中心、横断面回顾性研究旨在比较接受白藜芦醇补充剂（每天 200 毫克）连续治疗的女性（RES 组）与对照组（非 RES 组）的胚胎移植周期的结果。在 8686 个胚胎移植周期中，排除了 1409 个具有不良预后因素的周期，包括年龄≥43 岁的周期和胚胎质量差的周期。RES 组（204 个周期，102 名女性）与非 RES 组（7073 个周期，2958 名女性）进行比较。
在按取卵时的年龄、胚胎的等级和发育阶段、移植胚胎的数量以及新鲜或冷冻解冻胚胎移植进行患者匹配后，多变量逻辑回归分析表明，白藜芦醇补充与临床妊娠率降低显著相关[优势比（OR）0.539，95%置信区间（CI）0.341-0.853]，且流产风险增加（OR 2.602，95% CI 1.070-6.325）。
胚胎移植周期中白藜芦醇补充似乎对妊娠结局不利。需要对补充方案进行分析和开展随机对照研究。
