Osborn M, Caselitz J, Püschel K, Weber K
Max Planck Institute for Biophysical Chemistry, Göttingen, Federal Republic of Germany.
Virchows Arch A Pathol Anat Histopathol. 1987;411(5):449-58. doi: 10.1007/BF00735226.
Different regions of human aorta and of other human arteries obtained at autopsy were analyzed with regard to their topography and to the different stages of arteriosclerosis. Material was studied by immunocytochemical techniques with antibodies specific for either desmin (D) or for vimentin (V), the two types of intermediate filament proteins present in vascular smooth muscle cells. In normal arteries endothelial cells as well as the adjacent intimal cells were D-V+. In the media D+V+ as well as D-V+ cells were present, with the relative numbers of each cell type dependent on the particular blood vessel. When cells in arteriosclerotic plaques at different stages of development were examined an occasional plaque showed cells of the D+V+ type. In the majority of plaques however the cells were V-D+. In plaques where severe ulceration and necrotic material was present D-V+ cells were found at the border of the lesion: foam cells when they could be identified appeared to be D-V+.
对尸检获得的人体主动脉及其他人体动脉的不同区域，就其局部解剖结构和动脉粥样硬化的不同阶段进行了分析。采用免疫细胞化学技术，用针对结蛋白（D）或波形蛋白（V）的抗体对材料进行研究，这两种中间丝蛋白存在于血管平滑肌细胞中。在正常动脉中，内皮细胞以及相邻的内膜细胞呈D-V+。在中膜中，存在D+V+以及D-V+细胞，每种细胞类型的相对数量取决于特定的血管。当检查处于不同发育阶段的动脉粥样硬化斑块中的细胞时，偶尔有斑块显示出D+V+型细胞。然而，在大多数斑块中，细胞为V-D+。在存在严重溃疡和坏死物质的斑块中，在病变边界发现了D-V+细胞：当能够识别时，泡沫细胞似乎为D-V+。
