Zhang Furong, Chen Xixi, Wu Xiaoyan, Liu Xicen, Sun Mingsheng, Shen Xiaoyu, Li Juan, Zheng Hui, Jin Rongjiang
College of Health Preservation and Rehabilitation.
College of Acupuncture and Tuina, Chengdu University of Traditional Chinese Medicine.
Medicine (Baltimore). 2019 Jun;98(23):e15979. doi: 10.1097/MD.0000000000015979.
Traditional Chinese medicine (TCM) nonpharmacological interventions are gaining an increasing popularity for chronic pulmonary obstructive disease (COPD) treatment and rehabilitation, yet their comparative effectiveness and safety remains unclear. Therefore, this study will aim to compare their effectiveness and safety for COPD by implementing a network-meta analysis.
Electronic databases including MEDLINE via Ovid, and EMBASE via Ovid, the Cochrane Central Register of Controlled Trials (CENTRAL), China National Knowledge Infrastructure (CNKI) and Chinese BioMedical Literature Database (CBM) will be searched for related randomized controlled trials (RCTs) from inceptions to the search date without language restrictions. RCTs that compare TCM nonpharmacological interventions with placebo or conventional treatments will be included. The primary outcome will be lung function measures, dyspnea level and COPD-specified life quality and secondary ones will include functional exercise capacity, and general health-related life quality. Both classical meta-analysis and network meta-analysis will be implemented to investigate direct and indirect evidences on this topic. Continuous data will be expressed as standard mean differences (SMDs) and categorical data as risk ratios (RRs) with 95% confidence intervals. The evidence transitivity and consistency within network will be evaluated with Cochrane Q statistic and net-heat plot.
The study results will be disseminated through a peer-reviewed journal publication or conference presentation.
The review findings will provide a ranking evidence of current TCM nonpharmacological interventions and help to inform clinical practitioners, COPD patients, and policy-makers in the decision-making.
PROSPERO CRD42019126554.
中医非药物干预在慢性阻塞性肺疾病（COPD）的治疗和康复中越来越受欢迎，但其相对有效性和安全性仍不明确。因此，本研究旨在通过进行网状Meta分析来比较其对COPD的有效性和安全性。
将检索包括通过Ovid的MEDLINE、通过Ovid的EMBASE、Cochrane对照试验中央注册库（CENTRAL）、中国知网（CNKI）和中国生物医学文献数据库（CBM）在内的电子数据库，以查找从开始到检索日期的相关随机对照试验（RCT），无语言限制。将纳入比较中医非药物干预与安慰剂或传统治疗的RCT。主要结局将是肺功能指标、呼吸困难程度和COPD特定生活质量，次要结局将包括功能运动能力和一般健康相关生活质量。将实施经典Meta分析和网状Meta分析以研究该主题的直接和间接证据。连续数据将表示为标准均数差（SMD），分类数据将表示为风险比（RR），并带有95%置信区间。将使用Cochrane Q统计量和净热图评估网络内的证据传递性和一致性。
研究结果将通过同行评审的期刊发表或会议报告进行传播。
综述结果将提供当前中医非药物干预的排名证据，并有助于为临床医生、COPD患者和政策制定者的决策提供参考。
PROSPERO CRD42019126554。
