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1
Physiological significance of the alcohol dehydrogenase polymorphism in larvae of Drosophila.果蝇幼虫中乙醇脱氢酶多态性的生理意义。
Genetics. 1987 Sep;117(1):75-84. doi: 10.1093/genetics/117.1.75.
2
Alcohol dehydrogenase polymorphism in Drosophila: enzyme kinetics of product inhibition.果蝇中的乙醇脱氢酶多态性：产物抑制的酶动力学
J Mol Evol. 1988;28(1-2):145-50. doi: 10.1007/BF02143506.
3
Analysis of the gene encoding the multifunctional alcohol dehydrogenase allozyme ADH-71k of Drosophila melanogaster.黑腹果蝇多功能乙醇脱氢酶同工酶ADH - 71k编码基因的分析。
Mol Biol Evol. 1990 Sep;7(5):459-69. doi: 10.1093/oxfordjournals.molbev.a040614.
4
Alcohol dehydrogenase of Drosophila melanogaster: metabolic differences mediated through cryptic allozymes.黑腹果蝇的乙醇脱氢酶：由隐性等位酶介导的代谢差异
Heredity (Edinb). 1986 Aug;57 ( Pt 1):23-9. doi: 10.1038/hdy.1986.82.
5
Isolation of protease-free alcohol dehydrogenase (ADH) from Drosophila simulans and several homozygous and heterozygous Drosophila melanogaster variants.从拟暗果蝇以及几种纯合和杂合黑腹果蝇变体中分离无蛋白酶乙醇脱氢酶（ADH）。
Biochem Genet. 1998 Feb;36(1-2):15-36. doi: 10.1023/a:1018796002063.
6
Substrate and inhibitor specificities of the thermostable alcohol dehydrogenase allozymes ADH-71k and ADH-FCh.D. of Drosophila melanogaster.黑腹果蝇的热稳定乙醇脱氢酶同工酶ADH - 71k和ADH - FCh.D.的底物及抑制剂特异性
Biochem Genet. 1994 Apr;32(3-4):91-103. doi: 10.1007/BF00554418.
7
Ethanol tolerance and variation at the alcohol dehydrogenase (Adh) locus of Drosophila mauritiana.毛里求斯果蝇乙醇耐受性及乙醇脱氢酶（Adh）基因座的变异
Heredity (Edinb). 1995 Apr;74 ( Pt 4):438-44. doi: 10.1038/hdy.1995.61.
8
A MULTILEVEL APPROACH TO THE SIGNIFICANCE OF GENETIC VARIATION IN ALCOHOL DEHYDROGENASE OF DROSOPHILA.一种多层次探讨果蝇乙醇脱氢酶基因变异意义的方法
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Kinetics and thermodynamics of ethanol oxidation catalyzed by genetic variants of the alcohol dehydrogenase from Drosophila melanogaster and D. simulans.黑腹果蝇和拟果蝇乙醇脱氢酶基因变体催化乙醇氧化的动力学和热力学
Biochim Biophys Acta. 1988 Nov 17;967(2):224-33. doi: 10.1016/0304-4165(88)90013-x.
10
Drosophila alcohol dehydrogenase polymorphism and carbon-13 fluxes: opportunities for epistasis and natural selection.果蝇乙醇脱氢酶多态性与碳-13通量：上位性和自然选择的机遇
Genetics. 1994 Aug;137(4):1071-8. doi: 10.1093/genetics/137.4.1071.

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Human alcohol dehydrogenase 1 is an acceptor protein for polyADP-ribosylation.人醇脱氢酶 1 是多聚 ADP-核糖基化的受体蛋白。
Biochem Pharmacol. 2019 Sep;167:27-32. doi: 10.1016/j.bcp.2019.03.037. Epub 2019 Mar 29.
2
Experimental test and refutation of a classic case of molecular adaptation in Drosophila melanogaster.黑腹果蝇分子适应经典案例的实验测试与反驳
Nat Ecol Evol. 2017 Jan 13;1(2):25. doi: 10.1038/s41559-016-0025.
3
ALCOHOL TOLERANCE, ADH ACTIVITY, AND ECOLOGICAL NICHE OF DROSOPHILA SPECIES.果蝇物种的酒精耐受性、乙醇脱氢酶活性与生态位
Evolution. 1994 Jun;48(3):746-757. doi: 10.1111/j.1558-5646.1994.tb01358.x.
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Mechanisms of naturally evolved ethanol resistance in Drosophila melanogaster.黑腹果蝇自然进化出乙醇抗性的机制。
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Alcohol dehydrogenase activities and ethanol tolerance in Anastrepha (Diptera, Tephritidae) fruit-fly species and their hybrids.醇脱氢酶活性和乙醇耐受性在安氏亚种（双翅目，瘿蚊科）果蝇种及其杂种中的研究。
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6
Enzyme polymorphism in Drosophila melanogaster populations collected in two different habitats in Hungary.在匈牙利两个不同栖息地采集的黑腹果蝇种群中的酶多态性。
Genetica. 1995;96(3):257-68. doi: 10.1007/BF01439580.
7
Evolutionary genetics of the Drosophila alcohol dehydrogenase gene-enzyme system.果蝇乙醇脱氢酶基因-酶系统的进化遗传学
Genetica. 1993;92(1):1-22. doi: 10.1007/BF00057503.
8
Molecular analysis of an allozyme cline: alcohol dehydrogenase in Drosophila melanogaster on the east coast of North America.一种等位酶渐变群的分子分析：北美东海岸黑腹果蝇中的乙醇脱氢酶
Genetics. 1993 Jul;134(3):869-93. doi: 10.1093/genetics/134.3.869.
9
Drosophila alcohol dehydrogenase polymorphism and carbon-13 fluxes: opportunities for epistasis and natural selection.果蝇乙醇脱氢酶多态性与碳-13通量：上位性和自然选择的机遇
Genetics. 1994 Aug;137(4):1071-8. doi: 10.1093/genetics/137.4.1071.
10
Substrate and inhibitor specificities of the thermostable alcohol dehydrogenase allozymes ADH-71k and ADH-FCh.D. of Drosophila melanogaster.黑腹果蝇的热稳定乙醇脱氢酶同工酶ADH - 71k和ADH - FCh.D.的底物及抑制剂特异性
Biochem Genet. 1994 Apr;32(3-4):91-103. doi: 10.1007/BF00554418.

本文引用的文献

1
The molecular basis of dominance.显性的分子基础。
Genetics. 1981 Mar-Apr;97(3-4):639-66. doi: 10.1093/genetics/97.3-4.639.
2
Alcohol dehydrogenase from the fruitfly Drosophila melanogaster. Substrate specificity of the alleloenzymes AdhS and AdhUF.果蝇黑腹果蝇的乙醇脱氢酶。等位酶AdhS和AdhUF的底物特异性。
Biochim Biophys Acta. 1982 May 21;704(1):7-16. doi: 10.1016/0167-4838(82)90125-x.
3
Alcohol dehydrogenase from the fruitfly Drosophila melanogaster. Inhibition studies of the alleloenzymes AdhS and AdhUF.果蝇黑腹果蝇的乙醇脱氢酶。等位酶AdhS和AdhUF的抑制研究。
Biochim Biophys Acta. 1982 May 21;704(1):17-25. doi: 10.1016/0167-4838(82)90126-1.
4
Drosophila alcohol dehydrogenase: detoxification of isopropanol and acetone, substances not used in energy metabolism.果蝇乙醇脱氢酶：异丙醇和丙酮的解毒作用，这些物质不参与能量代谢。
Heredity (Edinb). 1981 Oct;47(2):263-8. doi: 10.1038/hdy.1981.83.
5
Evidence for biochemical and physiological differences between enzyme genotypes in Drosophila melanogaster.黑腹果蝇酶基因型之间生化和生理差异的证据。
Proc Natl Acad Sci U S A. 1981 Jul;78(7):4444-7. doi: 10.1073/pnas.78.7.4444.
6
Biochemical differences between products of the Adh locus in Drosophila.果蝇中乙醇脱氢酶（Adh）基因座产物之间的生化差异。
Genetics. 1980 Aug;95(4):1013-22. doi: 10.1093/genetics/95.4.1013.
7
Regulatory gene evolution: adaptive differences in expression of alcohol dehydrogenase in Drosophila melanogaster and Drosophila simulans.调控基因进化：黑腹果蝇和拟暗果蝇中乙醇脱氢酶表达的适应性差异
Heredity (Edinb). 1984 Apr;52 ( Pt 2):215-25. doi: 10.1038/hdy.1984.23.
8
Biochemical and molecular analysis of naturally occurring Adh variants in Drosophila melanogaster.黑腹果蝇中天然存在的乙醇脱氢酶变体的生化与分子分析
Proc Natl Acad Sci U S A. 1983 Aug;80(15):4798-802. doi: 10.1073/pnas.80.15.4798.
9
Regulation of sn-glycerol-3-phosphate dehydrogenase in Drosophila melanogaster larvae by dietary ethanol and sucrose.果蝇幼虫中饮食乙醇和蔗糖对sn-甘油-3-磷酸脱氢酶的调控
J Nutr. 1983 Aug;113(8):1632-42. doi: 10.1093/jn/113.8.1632.
10
The alcohol dehydrogenase alleloenzymes AdhS and AdhF from the fruitfly Drosophila melanogaster: an enzymatic rate assay to determine the active-site concentration.果蝇黑腹果蝇的乙醇脱氢酶等位酶AdhS和AdhF：一种用于测定活性位点浓度的酶促速率测定法。
Biochem Genet. 1985 Apr;23(3-4):205-16. doi: 10.1007/BF00504319.

果蝇幼虫中乙醇脱氢酶多态性的生理意义。

Physiological significance of the alcohol dehydrogenase polymorphism in larvae of Drosophila.

作者信息

Heinstra P W, Scharloo W, Thörig G E

机构信息

Department of Population and Evolutionary Biology, University of Utrecht, The Netherlands.

出版信息

Genetics. 1987 Sep;117(1):75-84. doi: 10.1093/genetics/117.1.75.

DOI:10.1093/genetics/117.1.75
PMID:3117619
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1203189/
Abstract

This study deals with biochemical and metabolic-physiological aspects of the relationship between variation in in vivo alcohol dehydrogenase activity and fitness in larvae homozygous for the alleles Adh71k, AdhF, AdhS, of Drosophila melanogaster, and for the common Adh allele of Drosophila simulans. The Adh genotypes differ in the maximum oxidation rates of propan-2-ol into acetone in vivo. There are smaller differences between the Adh genotypes in rates of ethanol elimination. Rates of accumulation of ethanol in vivo are negatively associated with larval-to-adult survival of the Adh genotypes. The rank order of the maximum rates of the ADHs in elimination of propan-2-ol, as well as ethanol, is ADH-71k greater than ADH-F greater than ADH-S greater than simulans-ADH. The ratio of this maximum rate to ADH quantity reveals the rank order of ADH-S greater than ADH-F greater than ADH-71k greater than simulans-ADH, suggesting a compensation for allozymic efficiency by the ADH quantity in D. melanogaster. Our findings show that natural selection may act on the Adh polymorphism in larvae via differences in rates of alcohol metabolism.

摘要

本研究探讨了黑腹果蝇等位基因Adh71k、AdhF、AdhS纯合幼虫以及拟果蝇常见Adh等位基因的体内乙醇脱氢酶活性变化与适应性之间关系的生化和代谢生理方面。Adh基因型在体内将丙-2-醇氧化为丙酮的最大氧化速率上存在差异。Adh基因型在乙醇消除速率上的差异较小。体内乙醇积累速率与Adh基因型的幼虫到成虫存活率呈负相关。ADH在消除丙-2-醇以及乙醇方面的最大速率排序为：ADH-71k大于ADH-F大于ADH-S大于拟果蝇-ADH。该最大速率与ADH量的比值显示出ADH-S大于ADH-F大于ADH-71k大于拟果蝇-ADH的排序，这表明黑腹果蝇中ADH量对同工酶效率具有补偿作用。我们的研究结果表明，自然选择可能通过酒精代谢速率的差异作用于幼虫的Adh多态性。