2015 年至 2018 年突尼斯分离的兔出血症病毒的遗传特征和系统进化分析。

Genetic characterization and phylogenetic analysis of rabbit hemorrhagic disease virus isolated in Tunisia from 2015 to 2018.

机构信息

Université de Tunis El Manar, Institut Pasteur de Tunis, LR11IPT01 Microbiologie Moléculaire, Vaccinologie et Développement Biotechnologique, 13, Place Pasteur BP-74, 1002, Tunis-Belvedere, Tunisia.

Institut de la Recherche Vétérinaire de Tunisie, Service Virologie, 20 Rue Djebel Lakhdar La Rabta, 1006, Tunis, Tunisia.

出版信息

Arch Virol. 2019 Sep;164(9):2327-2332. doi: 10.1007/s00705-019-04311-z. Epub 2019 Jun 8.

DOI:10.1007/s00705-019-04311-z

PMID:31177352

Abstract

Two distinct genotypes responsible for rabbit hemorrhagic disease (RHD) are reported, GI.1 (RHDV) and GI.2 (RHDV2). Vaccines based on these two genotypes are only partially cross-protective. Hence, knowing which genotype is circulating is important for appropriate control measures. We have investigated 25 field samples isolated between 2015 and 2018 from rabbits with clinical signs of RHD. Only GI.2 (RHDV2) is currently circulating in Tunisia. All Tunisian samples were grouped together with typical genotypic and phenotypic mutations. Therefore, we recommend initiating an extensive preventive vaccination program based on GI.2 vaccines in addition to a regular monitoring of the circulating lagoviruses.

摘要

两种不同的基因型导致兔出血症（RHD），GI.1（RHDV）和 GI.2（RHDV2）。基于这两种基因型的疫苗仅具有部分交叉保护作用。因此，了解哪种基因型在流行对于采取适当的控制措施很重要。我们调查了 2015 年至 2018 年间 25 个具有 RHD 临床症状的兔的田间样本。目前，突尼斯仅流行 GI.2（RHDV2）。所有突尼斯样本都与典型的基因型和表型突变聚集在一起。因此，我们建议除了定期监测循环的长尾病毒外，还应基于 GI.2 疫苗启动广泛的预防性疫苗接种计划。