作为一种具有高葡萄糖转化率特性的新型益生菌候选物。
as a novel probiotic candidate with high glucose conversion rate properties.
作者信息
Lavasani Paria Sadat, Motevaseli Elahe, Sanikhani Nafiseh Sadat, Modarressi Mohammad Hossein
机构信息
Department of Molecular Medicine, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Department of Medical Genetics, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
出版信息
Heliyon. 2019 Apr 28;5(4):e01571. doi: 10.1016/j.heliyon.2019.e01571. eCollection 2019 Apr.
Promoting general health in terms of obesity and diabetes prevention is recommended by health care systems. The objectives of this study were to isolate an efficient glucose-converting to cellulose and to evaluate the safety of the selected strain as a new generation of probiotics in the fight against obesity. Of the 97 samples, 43 strains were isolated and evaluated for their glucose conversion rate and 5 strains were examined for probiotic activities by assays. A strain with significant performance was fed to rats in order to determine its safety status . The results revealed that the strain K.X.1 had high level of glucose conversion rate and significant survival rate in acidic pH and bile salt. No adverse clinical signs and bacterial translocation to rats' organs were observed. The results showed that the strain of K.X.1 has suitable probiotic properties.
医疗保健系统建议从预防肥胖和糖尿病的角度促进总体健康。本研究的目的是分离出一种能高效将葡萄糖转化为纤维素的菌株，并评估所选菌株作为新一代益生菌在对抗肥胖方面的安全性。在97个样本中，分离出43株菌株并评估其葡萄糖转化率，通过试验对5株菌株进行了益生菌活性检测。为了确定其安全状况，将一株表现显著的菌株喂给大鼠。结果显示，菌株K.X.1具有较高的葡萄糖转化率，在酸性pH值和胆盐环境中有显著的存活率。未观察到大鼠出现不良临床症状以及细菌向大鼠器官的转移。结果表明，菌株K.X.1具有合适的益生菌特性。
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