几种药用植物及其复方制剂水醇提取物对四氧嘧啶诱导的糖尿病小鼠的降血糖活性
Antihyperglycemic Activity of Hydroalcoholic Extracts of Selective Medicinal Plants , , , and and Their Polyherbal Preparation in Alloxan-Induced Diabetic Mice.
作者信息
Mustafa Sodah Bint, Akram Muhammad, Muhammad Asif Hafiz, Qayyum Imran, Hashmi Asif Mehmood, Munir Naveed, Khan Fahad Said, Riaz Muhammad, Ahmad Saeed
机构信息
Department of Eastern Medicine and Surgery, Faculty of Medical and Health Sciences, The University of Poonch, Rawalakot, Azad Jammu and Kashmir, Pakistan.
Department of Eastern Medicine, Directorate of Medical Sciences, Government College University Faisalabad-Pakistan, Faisalabad, Pakistan.
出版信息
Dose Response. 2019 May 27;17(2):1559325819852503. doi: 10.1177/1559325819852503. eCollection 2019 Apr-Jun.
BACKGROUND
Diabetes mellitus is a metabolic disorder associated with relative or absolute insulin deficiency or resistance, characterized by hyperglycemia. Modern prescriptions such as pioglitazone have better therapeutic potential, but its side effects and financial burden for developing countries have motivated the researchers to find alternative natural drugs to compete hyperglycemia in patients with diabetes. The present study was conducted to explore the therapeutic potential of selected medicinal plants for the treatment of diabetes as an alternative to allopathic medicines.
METHOD
In present study, hydroalcoholic extracts of , , and and their polyherbal preparation (PHP) as compound drug were investigated for their antihyperglycemic potential in alloxan-induced diabetic mice. The study subjects (mice) were divided into different groups as normal control, diabetic control, pioglitazone treated (standard drug), test groups (plant extract treated 50, 100, and 150 mg/kg body weight), and PHP-treated group. Blood glucose concentration of all the study animals was determined by Glucose strip test. Qualitative phytochemical analysis of all the plant extracts was also performed following standard methods.
RESULT
It was investigated that treatment of alloxan-induced diabetic mice with hydroalcoholic extracts of studied medicinal plants showed significant ( < .05) effects on fasting blood glucose levels (from baseline to normal range) in a manner comparable to that of the reference drug, pioglitazone (1 mg/kg body weight intraperitoneal). The tested plant extracts significantly ( < .05) reduced the glucose concentration in blood of diabetes-induced mice in a dose-dependent manner.
CONCLUSION
It could be concluded that studied medicinal plants have antihyperglycemic activity. The study findings favor the use of traditional herbal medicinal practices for the management of diabetes that might due to the presence of bioactive phytoconstituents in plants. However, larger studies are required to identify, isolate, and characterize the bioactive phytoconstituents responsible for antihyperglycemic activity of studied medicinal plants.
背景
糖尿病是一种与相对或绝对胰岛素缺乏或抵抗相关的代谢紊乱疾病，其特征为高血糖。现代处方药物如吡格列酮具有较好的治疗潜力，但其副作用以及对发展中国家造成的经济负担促使研究人员寻找替代天然药物来对抗糖尿病患者的高血糖。本研究旨在探索所选药用植物作为对抗糖尿病的替代药物的治疗潜力。
方法
在本研究中，研究了[植物名称1]、[植物名称2]、[植物名称3]和[植物名称4]的水醇提取物及其作为复方药物的多草药制剂（PHP）对四氧嘧啶诱导的糖尿病小鼠的降血糖潜力。研究对象（小鼠）被分为不同组，即正常对照组、糖尿病对照组、吡格列酮治疗组（标准药物）、试验组（植物提取物按50、100和150mg/kg体重治疗）以及PHP治疗组。通过血糖仪测试法测定所有研究动物的血糖浓度。还按照标准方法对所有植物提取物进行了定性植物化学分析。
结果
研究发现，用所研究药用植物的水醇提取物治疗四氧嘧啶诱导的糖尿病小鼠，对空腹血糖水平（从基线降至正常范围）显示出显著（P < 0.05）效果，其方式与参考药物吡格列酮（1mg/kg体重腹腔注射）相当。测试的植物提取物以剂量依赖方式显著（P < 0.05）降低了糖尿病诱导小鼠血液中的葡萄糖浓度。
结论
可以得出结论，所研究的药用植物具有降血糖活性。研究结果支持使用传统草药疗法来管理糖尿病，这可能是由于植物中存在生物活性植物成分。然而，需要进行更大规模的研究来鉴定、分离和表征负责所研究药用植物降血糖活性的生物活性植物成分。
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