科茨病的晚期再激活
Late re-activation of Coats disease.
作者信息
Lertjirachai Itsara, Wood Edward H, Moinuddin Omar, Drenser Kimberly A
机构信息
Associated Retinal Consultants, William Beaumont Hospital, Royal Oak, MI, USA.
Department of Ophthalmology, Srinakharinwirot University, Bangkok, Thailand.
出版信息
Am J Ophthalmol Case Rep. 2019 Apr 25;15:100458. doi: 10.1016/j.ajoc.2019.100458. eCollection 2019 Sep.
PURPOSE
To report case of Coats disease with the longest known interval of disease quiescence prior to first reactivation (17 years).
OBSERVATION
A 25-year-old male was regularly followed for Coats disease since age 4. After initial treatment with cryoablation, disease quiescence was achieved at age 8. The disease activity was well controlled for 17 years after which he developed decreased vision in the right eye at age 25. Late reactivation of Coats disease was diagnosed and multiple treatments ensued. Despite aggressive therapy, the patient experienced progressive exudation warranting surgical management and eventually developed neovascular glaucoma.
CONCLUSION
Once diagnosed with Coats disease, lifelong monitoring is essential to early detection and treatment of potential disease reactivation. The interval between disease quiescence and reactivation is variable, with this case representing the longest known interval of disease quiescence prior to first reactivation (17 years).
目的
报告一例Coats病病例，其首次复发前疾病静止期为已知最长（17年）。
观察结果
一名25岁男性自4岁起就因Coats病接受定期随访。在最初接受冷冻消融治疗后，8岁时疾病进入静止期。疾病活动得到良好控制达17年，之后在25岁时他右眼视力下降。Coats病晚期复发被诊断出来，随后进行了多次治疗。尽管积极治疗，患者仍出现进行性渗出，需要手术治疗，最终发展为新生血管性青光眼。
结论
一旦被诊断为Coats病，终身监测对于早期发现和治疗潜在的疾病复发至关重要。疾病静止期和复发期之间的间隔是可变的，本病例代表了首次复发前已知最长的疾病静止期（17年）。
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