Nduka John Kanayochukwu, Kelle Henrietta Ijeoma, Amuka Johnpaul Onyenezi
Environmental Chemistry and Toxicology Research Unit, Pure and Industrial Chemistry Department, Nnamdi Azikiwe University, P.M.B. 5025, Awka, Anambra State, Nigeria.
Department of Pure and Applied Science, Faculty of Sciences National Open University, Abuja, Nigeria.
Toxicol Rep. 2019 May 10;6:449-456. doi: 10.1016/j.toxrep.2019.05.007. eCollection 2019.
Nigeria's economic problems which inhibited local production has resulted in massive importation of used automobiles. Most of these automobiles need some repairs and reworking, having outlived their lifespan in the manufacturer's country. This study centers on the human carcinogenic and non-carcinogenic health risk assessment of cadmium, chromium and nickel exposures from reworking of imported used vehicles. Scraped car paint dusts from 56 Japanese made cars were collected from 8 different panel beating (body works) workshops (A-H) in Southeastern Nigeria. They were homogenized, mixed, divided into fine particles, filtered and digested by standard method. The filtrates were assayed for cadmium, chromium and nickel with atomic absorption spectrophotometry (AAS, 200A), workshops F and D have the highest concentration (mg/kg) of Cd (3.58 ± 0.02) and (3.36 ± 0.04) and higher than levels in workshops A, B, C, E, G and H. Chromium (mg/kg) in workshops F and G were (2.87 ± 0.04) and (2.95 ± 0.06) and higher than the other workshops. Nickel in workshop A (3.84 ± 0.04) is close to other workshop values. The highest hazard quotients for adults were cadmium in workshops B (1.37E-01), D (1.69E-01), E (1.79E-01) (inhalation), chromium [workshops G (5.45E-02), F (5.29E-02) and C (5.24E-02) inhalation]. Nickel -workshop A (5.9E-03) for children (inhalation). HQ in children through ingestion is cadmium (3.72E-04) workshop F and ingestion- 3.21E-01(workshop F) while nickel is 1.06E-02 (workshop A).The highest cancer risks were in exponents -4,-7 and -8 (adult) and -3, -6 and -9 (children) for workshops A-H through inhalation, ingestion and dermal contact, exposures to scrap car paint dust may be of significant public health importance in Nigeria as it can add to body burden of some carcinogenic heavy metals.
尼日利亚抑制本地生产的经济问题导致了大量二手汽车的进口。这些汽车大多在原产国已超出使用寿命,需要一些维修和翻新。本研究聚焦于进口二手车翻新过程中镉、铬和镍暴露对人体致癌和非致癌健康风险的评估。从尼日利亚东南部8个不同的车身修理(车身作业)车间(A - H)收集了56辆日本制造汽车的刮落车漆粉尘。将其均质化、混合、分成细颗粒、过滤并采用标准方法消解。用原子吸收分光光度法(AAS,200A)对滤液中的镉、铬和镍进行测定,车间F和D的镉浓度(mg/kg)最高,分别为(3.58 ± 0.02)和(3.36 ± 0.04),高于车间A、B、C、E、G和H的水平。车间F和G的铬(mg/kg)分别为(2.87 ± 0.04)和(2.95 ± 0.06),高于其他车间。车间A的镍(3.84 ± 0.04)与其他车间的值相近。成人最高危害商数方面,车间B(1.37E - 01)、D(1.69E - 01)、E(1.79E - 01)的镉(吸入途径),车间G(5.45E - 02)、F(5.29E - 02)和C(�.24E - 02)的铬(吸入途径)。儿童最高危害商数方面,车间A的镍(5.9E - 03)(吸入途径)。儿童经口摄入的危害商数方面,车间F的镉为(3.72E - 04),车间F经口摄入为3.2E - 01,而车间A的镍为1.06E - 02。通过吸入、摄入和皮肤接触途径,车间A - H的最高癌症风险指数在成人中为 - 4、 - 7和 - 8,在儿童中为 - 3、 - 6和 - 9,接触刮落车漆粉尘可能对尼日利亚公众健康具有重大意义,因为它会增加人体某些致癌重金属的负担。