两种突变的故事：开始了解基于鸡蛋的流感疫苗的问题了吗？
A Tale of Two Mutations: Beginning to Understand the Problems with Egg-Based Influenza Vaccines?
机构信息
The WHO Collaborating Centre for Reference and Research on Influenza, The Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia; Department of Microbiology and Immunology, The University of Melbourne, The Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.
The WHO Collaborating Centre for Reference and Research on Influenza, The Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia; Department of Microbiology and Immunology, The University of Melbourne, The Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.
出版信息
Cell Host Microbe. 2019 Jun 12;25(6):773-775. doi: 10.1016/j.chom.2019.05.012.
The majority of influenza vaccines are produced in embryonated eggs, but mutations occur as human influenza A(H3N2) viruses adapt to grow in eggs. This can alter virus antigenicity. Wu et al. (2019) reveal that there are two mutually exclusive pathways for egg adaptation, which has potential implications for future egg-based influenza vaccines.
大多数流感疫苗是在鸡胚中生产的，但当人流感 A(H3N2)病毒适应在鸡蛋中生长时，会发生突变。这可能会改变病毒的抗原性。Wu 等人（2019 年）揭示了鸡蛋适应的两种相互排斥的途径，这对未来基于鸡蛋的流感疫苗具有潜在影响。
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