1 Laboratory for Earth Surface Processes, College of Urban and Environmental Sciences, Peking University , Beijing, China.
2 Department of Laboratory Medicine and Pathology, Faculty of Medicine and Dentistry, University of Alberta , Edmonton, Alberta, Canada.
Environ Health Perspect. 2019 Jun;127(6):67008. doi: 10.1289/EHP5044. Epub 2019 Jun 14.
Bisphenol S (BPS) has been widely substituted for bisphenol A (BPA) on thermal papers, but little is known about its skin absorption.
We compared the percutaneous absorption and biotransformation of BPS and BPA in vitro and in a controlled human trial.
Absorption and biotransformation of BPS and BPA were monitored across reconstructed human epidermis at two environmentally relevant doses over 25 h. In the human trial, five male participants handled thermal receipts containing BPS and washed their hands after 2 h. Urine (0-48 h) and serum (0-7.5h) were analyzed for target bisphenols, and one participant repeated the experiment with extended monitoring. BPS data were compared with published data for isotope-labeled BPA ([Formula: see text]) in the same participants.
At doses of 1.5 and [Formula: see text] applied to reconstructed human epidermis, the permeability coefficient of BPS (0.009 and [Formula: see text], respectively) was significantly lower than for BPA (0.036 and [Formula: see text], respectively), and metabolism of both bisphenols was negligible. In participants handling thermal receipts, the quantities of BPS and [Formula: see text] on hands was significantly correlated with maximum urinary event flux ([Formula: see text]), but the slope was lower for BPS than BPA ([Formula: see text] and 1.1, respectively). As a proportion of total urinary bisphenol, free BPS [[Formula: see text]: [Formula: see text]] was higher than for free BPA ([Formula: see text]). Postexposure maximum urinary BPS concentrations (0.93 to [Formula: see text]; [Formula: see text]) were in the 93-98th percentile range of BPS in background Canadians ([Formula: see text]; [Formula: see text]).
Both the in vitro and human studies suggested lower percutaneous absorption of BPS compared with BPA, but a lower biotransformation efficiency of BPS should also be considered in its evaluation as a BPA substitute. https://doi.org/10.1289/EHP5044.
双酚 S（BPS）已广泛替代双酚 A（BPA）用于热敏纸，但关于其皮肤吸收的信息知之甚少。
我们比较了 BPS 和 BPA 在体外和人体对照试验中的经皮吸收和生物转化。
在 25 小时内，用两种环境相关剂量分别监测 BPS 和 BPA 在重建人体表皮上的吸收和生物转化。在人体试验中，五名男性参与者处理含有 BPS 的热敏收据，2 小时后洗手。分析尿液（0-48 小时）和血清（0-7.5 小时）中的目标双酚，一名参与者在延长监测后重复该实验。将 BPS 数据与同一参与者中标记同位素的 BPA([Formula: see text])的已发表数据进行比较。
在应用于重建人体表皮的 1.5 和 [Formula: see text]剂量下，BPS 的渗透系数（分别为 0.009 和 [Formula: see text]）明显低于 BPA（分别为 0.036 和 [Formula: see text]），两种双酚的代谢可以忽略不计。在处理热敏收据的参与者中，手上的 BPS 和 [Formula: see text]的量与最大尿事件通量（[Formula: see text]）显著相关，但 BPS 的斜率低于 BPA（分别为 1.1 和 1.1）。作为总尿双酚的比例，游离 BPS [[Formula: see text]: [Formula: see text]]高于游离 BPA [[Formula: see text]]。暴露后最大尿 BPS 浓度（0.93 至 [Formula: see text]；[Formula: see text]）在加拿大背景人群中 BPS 的第 93-98 百分位范围（[Formula: see text]；[Formula: see text]）内。
无论是体外研究还是人体研究都表明，BPS 的经皮吸收低于 BPA，但在评估 BPS 作为 BPA 替代品时，还应考虑其较低的生物转化效率。https://doi.org/10.1289/EHP5044.
