Department of Clinical Diagnostics, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, Oczapowskiego 14, 10-957 Olsztyn, Poland.
Departamento de Química Analítica, Escuela Politécnica Superior, Universidad de Sevilla, C/Virgen de África, 7, E-41011 Sevilla, Spain.
Int J Environ Res Public Health. 2022 Apr 11;19(8):4600. doi: 10.3390/ijerph19084600.
Bisphenol A (BPA) is an organic substance widely used in the plastics industry. It penetrates food and environment and, as an endocrine disruptor, has detrimental effects on human organisms. Pet animals, which live in the immediate vicinity of humans, are also exposed to BPA; however, knowledge regarding the exposure of dogs to this substance is extremely scarce. This is the first study in which hair analysis has been used to biomonitor BPA in 30 dogs using liquid chromatography and tandem mass spectrometry techniques. The presence of BPA in concentration levels above the method detection limit (1.25 ng/g) was noted in 93.33% of samples. BPA concentration levels were found to range from 7.05 ng/g to 436 ng/g (mean 81.30 ng/g). Statistically significant differences in BPA concentration levels were found between animals with physiological weight and animals with abnormal weight (skinny and obese). In turn, differences between males and females, as well as between young, middle-aged and old dogs, were not statistically significant. The obtained results have clearly shown that hair analysis is a useful method to evaluate the exposure of dogs to BPA. This study also confirmed that dogs are exposed to BPA to a large extent, and this substance may play a role as a pathological factor in this animal species. However, many aspects connected to the influence of BPA on canine health status are unclear and need further study.
双酚 A（BPA）是一种广泛应用于塑料工业的有机物质。它会渗透到食物和环境中，作为一种内分泌干扰物，对人类机体产生有害影响。宠物动物生活在人类的附近，也会接触到 BPA；然而，关于狗暴露于这种物质的知识极其有限。这是第一项使用液相色谱-串联质谱技术通过毛发分析来监测 30 只狗体内 BPA 的研究。在 93.33%的样本中发现 BPA 的浓度超过了方法检测限（1.25ng/g）。BPA 的浓度范围为 7.05ng/g 至 436ng/g（平均值为 81.30ng/g）。在生理体重和异常体重（消瘦和肥胖）的动物之间，BPA 浓度存在统计学显著差异。相反，雄性和雌性之间以及年轻、中年和老年犬之间的差异没有统计学意义。研究结果清楚地表明，毛发分析是评估狗暴露于 BPA 的一种有用方法。本研究还证实，狗在很大程度上接触到了 BPA，这种物质可能在该动物物种中作为一种病理因素发挥作用。然而，与 BPA 对犬健康状况的影响相关的许多方面仍不清楚，需要进一步研究。
