Sulaiman Bin Abdullah Aba Al-Khail Centre for Interdisciplinary Research in Basic Sciences (SA-CIRBS) Faculty of Basic and Applied Sciences, International Islamic University, H-10, Islamabad, 44000, Pakistan.
Department of Physical Chemistry, University of Vienna, Weahringer Strasse 38, 1090, Vienna, Austria.
Appl Biochem Biotechnol. 2019 Dec;189(4):1156-1166. doi: 10.1007/s12010-019-03049-3. Epub 2019 Jun 14.
A highly sensitive, selective, reversible, and reusable glucose sensor is developed by using molecularly imprinted polymer-based artificial receptors onto interdigital transducer. Sensor receptors were synthesized through bulk imprinting technology by using styrene as monomer, ethylene glycol dimethacrylate (EGDMA) as cross-linker, and AIBN as free radical initiator. Topography of the synthesized receptors was investigated by scanning electron microscopy (SEM). Fabricated sensor showed concentration-dependent linear and reversible response with lower limit of detection of 30 ppb and upper limit of detection ~ 500 ppm. Furthermore, newly fabricated sensor is highly selective towards its analyte of interest in the presence of other competing agents, and the regeneration of sensor response has been assessed with the percentage error of less than 2% under the period of 1 year at room temperature and pressure conditions. The reported sensor may have potential technological applications in the field of medical diagnostics, food, and pharmaceutical industry.
本文采用基于分子印迹聚合物的人工受体在叉指换能器上构建了一种高灵敏度、选择性、可逆和可重复使用的葡萄糖传感器。通过本体聚合技术，以苯乙烯为单体、乙二醇二甲基丙烯酸酯（EGDMA）为交联剂、AIBN 为自由基引发剂合成了传感器受体。通过扫描电子显微镜（SEM）研究了合成受体的形貌。所制备的传感器表现出与浓度相关的线性和可逆响应，检测下限为 30ppb，检测上限约为 500ppm。此外，新制备的传感器在存在其他竞争试剂的情况下对其目标分析物具有高选择性，并且在室温、常压条件下，传感器响应的再生已在 1 年内评估，其误差百分比小于 2%。该报道的传感器在医学诊断、食品和制药工业等领域可能具有潜在的技术应用。
