From the Department of Pediatrics, Division of Pediatric Infectious Diseases, Immunology and Rheumatology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.
Section of Pediatrics, Division of Infectious Diseases, Department of Medicine, Imperial College London, London, United Kingdom.
Pediatr Infect Dis J. 2019 Jun;38(6S Suppl 1):S7-S13. doi: 10.1097/INF.0000000000002318.
Biomarkers have become an integral part of the clinical decision-making process of clinicians dealing with febrile children. C-reactive protein, procalcitonin and white blood cell count are probably the most studied ones. Crucial to using biomarkers is the understanding of how a test result will alter post-test probabilities and then impact on clinical decision making. Improved analytical and computational platforms have enabled the next generation of advanced biomarker discovery studies. Promising combinations of candidate biomarkers for a diverse spectrum of febrile illnesses, such as viral and bacterial infections, have been identified using proteomics, RNA gene expression and metabolomics.
生物标志物已成为临床医生处理发热儿童临床决策过程不可或缺的一部分。C 反应蛋白、降钙素原和白细胞计数可能是研究最多的生物标志物。使用生物标志物的关键是了解测试结果将如何改变测试后概率，然后对临床决策产生影响。改进的分析和计算平台使新一代先进的生物标志物发现研究成为可能。使用蛋白质组学、RNA 基因表达和代谢组学已经鉴定出了针对各种发热疾病（如病毒和细菌感染）的候选生物标志物的有希望的组合。
