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长链非编码 RNA-LOC101928316 通过调控 PI3K-Akt-mTOR 信号通路促进胃癌进展。

LncRNA-LOC101928316 contributes to gastric cancer progression through regulating PI3K-Akt-mTOR signaling pathway.

机构信息

Department of Toxicology, School of Public Health, Lanzhou University, Lanzhou, China.

Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing, China.

出版信息

Cancer Med. 2019 Aug;8(9):4428-4440. doi: 10.1002/cam4.2165. Epub 2019 Jun 17.

DOI:10.1002/cam4.2165
PMID:31207155
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6675725/
Abstract

Long noncoding RNA (lncRNA) has played the important function in regulation of various biological processes and in diagnostic value has been widely appreciated. In the present study, we have found that LOC101928316 was significantly downregulated in gastric cancer (GC) tissues specimen, GC cell lines, and associated with the GC patients tumor, node, and metastasis (TNM) stage and degree of differentiation (P ＜ 0.05). LOC101928316 overexpression can significantly inhibit SGC-7901 cell migration, invasion, and proliferation (P＜0.05). LOC101928316 molecular mechanism investigates suggested that LOC101928316 can regulate PI3K-Akt-mTOR signaling pathway and change the GC development progression in vivo and in vitro. In vivo experiment also revealed that LOC101928316-Overexpression can inhibit the tumorigenicity of GC cells in tumor-burdened experimental nude mice (P ＜ 0.05). LOC101928316 may function as anti-oncogene and also plays an important role in GC tumorigenesis. Collectively, our data provided the key role of LOC101928316 in the tumorigenesis of GC. In addition, the present study elucidates LOC101928316 potential regulatory network, which may help us to lead a better knowing of the pathogenesis of GC and probe the lncRNA as a novel biomarker to diagnosis and therapy for this malignant tumor.

摘要

长链非编码 RNA（lncRNA）在调节多种生物过程中发挥着重要作用，其在诊断中的价值已得到广泛认可。在本研究中，我们发现 LOC101928316 在胃癌（GC）组织标本、GC 细胞系中显著下调，并与 GC 患者的肿瘤、淋巴结和转移（TNM）分期和分化程度相关（P＜0.05）。过表达 LOC101928316 可显著抑制 SGC-7901 细胞的迁移、侵袭和增殖（P＜0.05）。LOC101928316 的分子机制研究表明，LOC101928316 可调节 PI3K-Akt-mTOR 信号通路，并改变体内和体外 GC 的发展进程。体内实验还表明，LOC101928316-过表达可抑制荷瘤实验裸鼠 GC 细胞的致瘤性（P＜0.05）。LOC101928316 可能作为抑癌基因发挥作用，在 GC 肿瘤发生中也发挥着重要作用。综上所述，我们的数据提供了 LOC101928316 在 GC 肿瘤发生中的关键作用。此外，本研究阐明了 LOC101928316 的潜在调控网络，这可能有助于我们更好地了解 GC 的发病机制，并探索 lncRNA 作为诊断和治疗这种恶性肿瘤的新型生物标志物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a5a8/6675725/8085bc768a2c/CAM4-8-4428-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a5a8/6675725/daa57d78ea81/CAM4-8-4428-g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a5a8/6675725/0b22e8c526a1/CAM4-8-4428-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a5a8/6675725/6870e8bbacc6/CAM4-8-4428-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a5a8/6675725/72f1553efdae/CAM4-8-4428-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a5a8/6675725/753c4ef05d14/CAM4-8-4428-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a5a8/6675725/d147aa1fec90/CAM4-8-4428-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a5a8/6675725/588cb6de20db/CAM4-8-4428-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a5a8/6675725/be6c7c2f0e78/CAM4-8-4428-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a5a8/6675725/8085bc768a2c/CAM4-8-4428-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a5a8/6675725/daa57d78ea81/CAM4-8-4428-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a5a8/6675725/d3aa9d9ff347/CAM4-8-4428-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a5a8/6675725/0269e88e0fe3/CAM4-8-4428-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a5a8/6675725/f1b30c44d331/CAM4-8-4428-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a5a8/6675725/4197e25e1821/CAM4-8-4428-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a5a8/6675725/0b22e8c526a1/CAM4-8-4428-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a5a8/6675725/6870e8bbacc6/CAM4-8-4428-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a5a8/6675725/72f1553efdae/CAM4-8-4428-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a5a8/6675725/753c4ef05d14/CAM4-8-4428-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a5a8/6675725/d147aa1fec90/CAM4-8-4428-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a5a8/6675725/588cb6de20db/CAM4-8-4428-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a5a8/6675725/be6c7c2f0e78/CAM4-8-4428-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a5a8/6675725/8085bc768a2c/CAM4-8-4428-g013.jpg

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