Institute of Pharmacy, Pharmacognosy, University of Innsbruck, Innrain 80-82, 6020 Innsbruck, Austria.
Institute of Biological Sciences, Applied Ecology & Phycology, University of Rostock, Albert-Einstein-Str. 3, 18059 Rostock, Germany.
Mar Drugs. 2019 Jun 14;17(6):356. doi: 10.3390/md17060356.
Various red algae have repeatedly been reported to produce a variety of UV-absorbing mycosporine-like amino acids (MAAs), compounds that are well-known as natural sun-screens, as well as a plethora of betaines, metabolites which contribute to the osmotic balance under salt stress. Among other Rhodophyta, , which is thriving as epiphyte on salt marsh plants in Europe and hence experiences extreme environmental conditions such as desiccation, UV-stress and osmotic stress, has barely been investigated for its secondary metabolites. In the present study, seven mycosporine like-amino acids and two betaines were isolated from using various chromatographic techniques. Their structures were confirmed by Nuclear Magnetic Resonance (NMR) spectroscopy and High Resolution Mass Spectrometry (HRMS). Six MAAs and one betaine were chemically characterized as new natural products.
各种红藻一再被报道能够产生多种具有紫外线吸收能力的菌多酚胺类氨基酸（MAAs），这些化合物是众所周知的天然防晒霜，同时还能产生大量的甜菜碱，这些代谢物有助于在盐胁迫下保持渗透平衡。在其他红藻中， 作为欧洲盐沼植物的附生植物而大量存在，因此经历了极端的环境条件，如干燥、紫外线胁迫和渗透胁迫，其次生代谢产物几乎没有被研究过。在本研究中，使用各种色谱技术从 中分离出七种菌多酚胺类氨基酸和两种甜菜碱。它们的结构通过核磁共振（NMR）光谱和高分辨率质谱（HRMS）得到了确认。六种 MAAs 和一种甜菜碱被化学表征为新的天然产物。
