相似文献

1

Isolation and Structure Elucidation of Novel Mycosporine-like Amino Acids from the Two Intertidal Red Macroalgae and .

Mar Drugs. 2023 Oct 18;21(10):543. doi: 10.3390/md21100543.

2

Analysis of the Mycosporine-Like Amino Acid (MAA) Pattern of the Salt Marsh Red Alga .

Mar Drugs. 2021 May 31;19(6):321. doi: 10.3390/md19060321.

3

Bostrychines A-F, Six Novel Mycosporine-Like Amino-Acids and a Novel Betaine from the Red Alga .

Mar Drugs. 2019 Jun 14;17(6):356. doi: 10.3390/md17060356.

4

Photo-protective compounds in red macroalgae from Brittany: Considerable diversity in mycosporine-like amino acids (MAAs).

Mar Environ Res. 2019 May;147:37-48. doi: 10.1016/j.marenvres.2019.04.001. Epub 2019 Apr 6.

5

Seasonal Variation of Mycosporine-Like Amino Acids in Three Subantarctic Red Seaweeds.

Mar Drugs. 2020 Jan 24;18(2):75. doi: 10.3390/md18020075.

6

Chemical profiling of mycosporine-like amino acids in twenty-three red algal species.

J Phycol. 2019 Apr;55(2):393-403. doi: 10.1111/jpy.12827. Epub 2019 Jan 31.

7

Chemotaxonomic Study of spp. (Ceramiales, Rhodophyta) Based on Their Mycosporine-Like Amino Acid Content.

Molecules. 2020 Jul 17;25(14):3273. doi: 10.3390/molecules25143273.

8

Analysis of Mycosporine-Like Amino Acids in Selected Algae and Cyanobacteria by Hydrophilic Interaction Liquid Chromatography and a Novel MAA from the Red Alga Catenella repens.

Mar Drugs. 2015 Oct 9;13(10):6291-305. doi: 10.3390/md13106291.

9

Extraction, Isolation and Characterization of Mycosporine-like Amino Acids from Four Species of Red Macroalgae.

Mar Drugs. 2021 Oct 28;19(11):615. doi: 10.3390/md19110615.

10

The influence of environmental features in the content of mycosporine-like amino acids in red marine algae along the Brazilian coast.

J Phycol. 2018 Jun;54(3):380-390. doi: 10.1111/jpy.12640. Epub 2018 Apr 6.

引用本文的文献

1

Neuroprotective Mechanisms of -Derived Bioactive Compounds in Alzheimer's Disease: An Overview of Novel Insights.

Mar Drugs. 2025 Jun 30;23(7):274. doi: 10.3390/md23070274.

2

Diversity of Bioactive Compounds in Microalgae: Key Classes and Functional Applications.

Mar Drugs. 2025 May 22;23(6):222. doi: 10.3390/md23060222.

本文引用的文献

1

Sublethal consequences of ultraviolet radiation exposure on vertebrates: Synthesis through meta-analysis.

Glob Chang Biol. 2023 Dec;29(23):6620-6634. doi: 10.1111/gcb.16848. Epub 2023 Jun 27.

2

Ultraviolet radiation shapes dendritic cell leukaemia transformation in the skin.

Nature. 2023 Jun;618(7966):834-841. doi: 10.1038/s41586-023-06156-8. Epub 2023 Jun 7.

3

Exploring Mycosporine-like Amino Acid UV-Absorbing Natural Products for a New Generation of Environmentally Friendly Sunscreens.

Mar Drugs. 2023 Apr 19;21(4):253. doi: 10.3390/md21040253.

4

Exploring the Relationship between Biosynthetic Gene Clusters and Constitutive Production of Mycosporine-like Amino Acids in Brazilian Cyanobacteria.

Molecules. 2023 Feb 2;28(3):1420. doi: 10.3390/molecules28031420.

5

Ozone Layer Depletion and Emerging Public Health Concerns - An Update on Epidemiological Perspective of the Ambivalent Effects of Ultraviolet Radiation Exposure.

Front Oncol. 2022 Mar 10;12:866733. doi: 10.3389/fonc.2022.866733. eCollection 2022.

6

Sunscreen Effect Exerted by Secondary Carotenoids and Mycosporine-like Amino Acids in the Aeroterrestrial Chlorophyte under High Light and UV-A Irradiation.

Plants (Basel). 2021 Nov 26;10(12):2601. doi: 10.3390/plants10122601.

7

Microalgae as a Source of Mycosporine-like Amino Acids (MAAs); Advances and Future Prospects.

Int J Environ Res Public Health. 2021 Nov 25;18(23):12402. doi: 10.3390/ijerph182312402.

8

Analysis of the Mycosporine-Like Amino Acid (MAA) Pattern of the Salt Marsh Red Alga .

Mar Drugs. 2021 May 31;19(6):321. doi: 10.3390/md19060321.

9

Exploring Mycosporine-Like Amino Acids (MAAs) as Safe and Natural Protective Agents against UV-Induced Skin Damage.

Antioxidants (Basel). 2021 Apr 27;10(5):683. doi: 10.3390/antiox10050683.

10

Mycosporine-Like Amino Acids (MAAs): Biology, Chemistry and Identification Features.

Pharmaceuticals (Basel). 2021 Jan 14;14(1):63. doi: 10.3390/ph14010063.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

文档翻译

学术文献翻译模型，支持多种主流文档格式。

从两种潮间带红大型海藻和中分离并阐明新型菌草氨酸类氨基酸。

Isolation and Structure Elucidation of Novel Mycosporine-like Amino Acids from the Two Intertidal Red Macroalgae and .

机构信息

Institute of Pharmacy, Pharmacognosy, University of Innsbruck, Innrain 80-82, 6020 Innsbruck, Austria.

Institute of Biological Sciences, Applied Ecology & Phycology, University of Rostock, Albert-Einstein-Str. 3, 18059 Rostock, Germany.

出版信息

Mar Drugs. 2023 Oct 18;21(10):543. doi: 10.3390/md21100543.

DOI:10.3390/md21100543

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10608480/

Abstract

This study presents a phytochemical survey of two common intertidal red algal species, and , regarding their MAA (mycosporine-like amino acid) composition, which are known as biogenic sunscreen compounds. Six novel MAAs from named bostrychines and two novel MAAs from named catenellines were isolated using a protocol which included silica gel column chromatography, flash chromatography on reversed phase material and semipreparative HPLC (High-Performance Liquid Chromatography). The structure of the novel MAAs was elucidated using NMR (Nuclear Magnetic Resonance) and HR-MS (High-Resolution Mass Spectrometry), and their absolute configuration was confirmed by ECD (Electronic Circular Dichroism). All isolated MAAs possess a cyclohexenimine scaffold, and the metabolites from . are related to the known MAAs bostrychines A-F, which contain glutamine, glutamic acid and/or threonine in their side chains. The new MAAs from . contain taurine, an amino sulfonic acid that is also present in another MAA isolated from this species, namely, catenelline. Previous and new data confirm that intertidal red algae are chemically rich in MAAs, which explains their high tolerance against biologically harmful ultraviolet radiation.

摘要

本研究对两种常见的潮间带红藻和进行了植物化学调查，研究其 MAAs（菌孢氨酸类似物氨基酸）组成，这些化合物是已知的生物防晒化合物。从中分离出了六种新的 MAAs，命名为 bostrychines，从中分离出了两种新的 MAAs，命名为 catenellines，采用的方法包括硅胶柱层析、反相材料的快速色谱和半制备高效液相色谱（HPLC）。通过 NMR（核磁共振）和 HR-MS（高分辨率质谱）确定了新 MAAs 的结构，并通过 ECD（电子圆二色性）确定了它们的绝对构型。所有分离出的 MAAs 都具有环己烯亚胺骨架，而中的代谢物与已知的 MAAs bostrychines A-F 有关，这些 MAAs 的侧链含有谷氨酰胺、谷氨酸和/或苏氨酸。中的新 MAAs 含有牛磺酸，这是一种氨基磺酸，也存在于该物种中另一种 MAA 即 catenelline 中。先前和新的数据证实，潮间带红藻在化学上富含 MAAs，这解释了它们对生物有害的紫外线辐射的高耐受性。