Department of Pharmacology, School of Pharmacy, Fourth Military Medical University, Xi'an, China.
Curr Genet. 2020 Feb;66(1):43-49. doi: 10.1007/s00294-019-01005-6. Epub 2019 Jun 17.
Bacterial cell division is a highly controlled process regulated accurately by a diverse array of proteins spatially and temporally working together. Among these proteins, FtsZ is recognized as a cytoskeleton protein because it can assemble into a ring-like structure called Z-ring at midcell. Z-ring recruits downstream proteins, thus forming a multiprotein complex termed the divisome. When the Z-ring scaffold is established and the divisome matures, peptidoglycan (PG) biosynthesis and chromosome segregation are triggered. In this review, we focus on multiple interactions between FtsZ and its accessory proteins in bacterial cell cytokinesis, including FtsZ localization, Z-ring formation and stabilization, PG biosynthesis, and chromosome segregation. Understanding the interactions among these proteins may help discover superior targets on treating bacterial infectious diseases.
细菌细胞分裂是一个高度受控的过程，由多种蛋白质在时空上精确调节，共同作用。在这些蛋白质中，FtsZ 被认为是一种细胞骨架蛋白，因为它可以在细胞中部组装成一个称为 Z 环的环状结构。Z 环招募下游蛋白质，从而形成一个称为分裂体的多蛋白复合物。当 Z 环支架建立并分裂体成熟时，肽聚糖（PG）生物合成和染色体分离被触发。在这篇综述中，我们重点介绍了 FtsZ 与其在细菌细胞胞质分裂中的辅助蛋白之间的多种相互作用，包括 FtsZ 的定位、Z 环的形成和稳定、PG 生物合成以及染色体分离。了解这些蛋白质之间的相互作用可能有助于发现治疗细菌感染性疾病的更好靶点。
