Department of Geriatrics, the Center for Translational Research in Aging & Longevity, Donald W. Reynolds Institute on Aging, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.
Department of Molecular Medicine, Lee Gil Ya Cancer and Diabetes Institute, Gachon University School of Medicine, Incheon 21999, Korea.
Nutrients. 2019 Jun 17;11(6):1360. doi: 10.3390/nu11061360.
Heart failure in older individuals is normally associated with a high body mass index and relatively low lean body mass due to, in part, a resistance to the normal anabolic effect of dietary protein. In this study we have investigated the hypothesis that consumption of a specially-formulated composition of essential amino acids (HiEAAs) can overcome anabolic resistance in individuals with heart failure and stimulate the net gain of body protein to a greater extent than a commercially popular protein-based meal replacement beverage with greater caloric but lower essential amino acid (EAA) content (LoEAA). A randomized cross-over design was used. Protein kinetics were determined using primed continuous infusions of L-(H)phenylalanine and L-(H)tyrosine in the basal state and for four hours following consumption of either beverage. Both beverages induced positive net protein balance (i.e., anabolic response). However, the anabolic response was more than two times greater with the HiEAA than the LoEAA ( < 0.001), largely through a greater suppression of protein breakdown ( < 0.001). Net protein accretion (g) was also greater in the HiEAA when data were normalized for either amino acid or caloric content ( < 0.001). We conclude that a properly formulated EAA mixture can elicit a greater anabolic response in individuals with heart failure than a protein-based meal replacement. Since heart failure is often associated with obesity, the minimal caloric value of the HiEAA formulation is advantageous.
老年人心力衰竭通常与高体重指数和相对低的瘦体重有关，部分原因是对膳食蛋白质的正常合成代谢作用产生抵抗。在这项研究中，我们假设，摄入专门配制的必需氨基酸（HiEAA）混合物可以克服心力衰竭个体的合成代谢抵抗，并比具有更高卡路里但必需氨基酸（EAA）含量较低的商业上流行的蛋白质基代餐饮料（LoEAA）更能刺激身体蛋白质的净获得。采用随机交叉设计。在基础状态和饮用任何饮料后 4 小时内，使用 L-（H）苯丙氨酸和 L-（H）酪氨酸的脉冲连续输注来确定蛋白质动力学。两种饮料均诱导正净蛋白平衡（即合成代谢反应）。然而，与 LoEAA 相比，HiEAA 的合成代谢反应高出两倍以上（<0.001），主要是通过更大程度地抑制蛋白质分解（<0.001）。当根据氨基酸或热量含量对数据进行归一化时，HiEAA 中的净蛋白积累（g）也更大（<0.001）。我们得出结论，适当配制的 EAA 混合物可以在心力衰竭个体中引起比蛋白质基代餐更大的合成代谢反应。由于心力衰竭常与肥胖有关，因此 HiEAA 配方的卡路里值最低是有利的。
