Department of Radiological Technology, Nagoya University Hospital.
Department of Radiology, Graduate School of Medicine, Nagoya University.
Magn Reson Med Sci. 2020 Aug 3;19(3):168-175. doi: 10.2463/mrms.mp.2019-0016. Epub 2019 Jun 20.
This study aimed to evaluate comprehensively; accuracy, repeatability and reproducibility of T and T relaxation times measured by magnetic resonance fingerprinting using B-corrected fast imaging with steady-state precession (FISP-MRF).
The International Society of Magnetic Resonance in Medicine/National Institute of Standards and Technology (ISMRM/NIST) phantom was scanned for 100 days, and six healthy volunteers for 5 days using a FISP-MRF prototype sequence. Accuracy was evaluated on the phantom by comparing relaxation times measured by FISP-MRF with the reference values provided by the phantom manufacturer. Daily repeatability was characterized as the coefficient of variation (CV) of the measurements over 100 days for the phantom and over 5 days for volunteers. In addition, the cross-scanner reproducibility was evaluated in volunteers.
In the phantom study, T and T values from FISP-MRF showed a strong linear correlation with the reference values of the phantom (R = 0.9963 for T; R = 0.9966 for T). CVs were <1.0% for T values larger than 300 ms, and <3.0% for T values across a wide range. In the volunteer study, CVs for both T and T values were <5.0%, except for one subject. In addition, all T values estimated by FISP-MRF in vivo were lower than those measured with conventional mapping sequences reported in previous studies. The cross-scanner variation of T and T showed good agreement between two different scanners in the volunteers.
B-corrected FISP-MRF showed an acceptable accuracy, repeatability and reproducibility in the phantom and volunteer studies.
本研究旨在全面评估磁共振指纹成像（MRF）中使用 B 校正快速稳态进动成像（FISP-MRF）测量 T 和 T 弛豫时间的准确性、可重复性和可再现性。
使用 FISP-MRF 原型序列对国际磁共振学会/美国国家标准与技术研究院（ISMRM/NIST）体模进行了 100 天扫描，对 6 名健康志愿者进行了 5 天扫描。在体模上通过比较 FISP-MRF 测量的弛豫时间与体模制造商提供的参考值来评估准确性。每日可重复性通过体模上 100 天和志愿者上 5 天的测量值的变异系数（CV）来描述。此外，在志愿者中评估了跨扫描仪的可再现性。
在体模研究中，FISP-MRF 的 T 和 T 值与体模的参考值具有很强的线性相关性（T 值的 R = 0.9963；T 值的 R = 0.9966）。T 值大于 300ms 时，CV 值小于 1.0%，T 值在较宽范围内时，CV 值小于 3.0%。在志愿者研究中，T 和 T 值的 CV 值均小于 5.0%，除了一个志愿者。此外，FISP-MRF 体内测量的所有 T 值均低于以前研究中报道的常规映射序列测量的 T 值。志愿者中 T 和 T 值的跨扫描仪变化在两个不同的扫描仪之间具有良好的一致性。
在体模和志愿者研究中，B 校正 FISP-MRF 显示出可接受的准确性、可重复性和可再现性。
