长链非编码RNA LINC00337通过抑制EZH2介导的p21来促进胃癌增殖。
Long noncoding RNA LINC00337 promote gastric cancer proliferation through repressing p21 mediated by EZH2.
作者信息
Hu Bo, Wang Xiaoye, Li Long
机构信息
Department of Pediatric Surgery, Tianjin Medical University General Hospital Tianjin, China.
Department of General surgery, Capital Institute of Pediatrics Children's Hospital Beijing, China.
出版信息
Am J Transl Res. 2019 May 15;11(5):3238-3245. eCollection 2019.
Abstract
Gastric cancer is one of the most common human malignancies. Some long noncoding RNA (lncRNA) has been validated to be oncogene in gastric cancer. In this research, we found that LINC00337 was up-regulated in the gastric cancer cells and tissue specimens. Clinically, the ectopic LINC00337 overexpression indicates the poor clinical outcome. The functional experiments illustrated that LINC00337 silencing repressed the proliferation, invasion and tumor growth in vitro and in vivo. The mechanical experiments showed that LINC00337 epigenetically repressed the p21 via EZH2-mediated inhibition. Overall, this finding suggests that LINC00337 acts as the oncogene to promote gastric cancer cells proliferation through epigenetically repressing p21 mediated by EZH2, providing a new insight for gastric cancer.
摘要
胃癌是人类最常见的恶性肿瘤之一。一些长链非编码RNA（lncRNA）已被证实为胃癌中的癌基因。在本研究中，我们发现LINC00337在胃癌细胞和组织标本中表达上调。临床上，异位LINC00337过表达提示临床预后不良。功能实验表明，LINC00337沉默在体外和体内均抑制了细胞增殖、侵袭及肿瘤生长。机制实验表明，LINC00337通过EZH2介导的抑制作用对p21进行表观遗传抑制。总体而言，这一发现表明LINC00337作为癌基因，通过EZH2介导的对p21的表观遗传抑制作用促进胃癌细胞增殖，为胃癌研究提供了新的见解。
相似文献
1
Long noncoding RNA LINC00337 promote gastric cancer proliferation through repressing p21 mediated by EZH2.
Am J Transl Res. 2019 May 15;11(5):3238-3245. eCollection 2019.
2
Long noncoding RNA LINC00337 accelerates the non-small-cell lung cancer progression through inhibiting TIMP2 by recruiting DNMT1.
Am J Transl Res. 2019 Sep 15;11(9):6075-6083. eCollection 2019.
3
LncRNA LINC00337 sponges mir-1285-3p to promote proliferation and metastasis of lung adenocarcinoma cells by upregulating YTHDF1.
Cancer Cell Int. 2021 Oct 18;21(1):550. doi: 10.1186/s12935-021-02253-8.
4
Long noncoding RNA TP73-AS1 accelerates the epithelial ovarian cancer via epigenetically repressing p21.
Am J Transl Res. 2019 Apr 15;11(4):2447-2454. eCollection 2019.
5
Long noncoding RNA Linc00337 functions as an E2F1 co-activator and promotes cell proliferation in pancreatic ductal adenocarcinoma.
J Exp Clin Cancer Res. 2020 Oct 14;39(1):216. doi: 10.1186/s13046-020-01725-5.
6
LINC00337 promotes tumor angiogenesis in colorectal cancer by recruiting DNMT1, which suppresses the expression of CNN1.
Cancer Gene Ther. 2021 Dec;28(12):1285-1297. doi: 10.1038/s41417-020-00277-2. Epub 2020 Dec 16.
7
Long noncoding RNA AFAP1-AS1 predicts a poor prognosis and regulates non-small cell lung cancer cell proliferation by epigenetically repressing p21 expression.
Mol Cancer. 2018 May 24;17(1):92. doi: 10.1186/s12943-018-0836-7.
8
Silencing of linc00337 inhibits proliferation, cell cycle progression, migration, and invasion of colorectal cancer cells through the MEK/ERK pathway.
Eur Rev Med Pharmacol Sci. 2020 May;24(10):5353-5359. doi: 10.26355/eurrev_202005_21318.
9
LINC00337 induces tumor development and chemoresistance to paclitaxel of breast cancer by recruiting M2 tumor-associated macrophages.
Mol Immunol. 2021 Oct;138:1-9. doi: 10.1016/j.molimm.2021.07.009. Epub 2021 Jul 24.
10
EZH2 promotes gastric cancer cells proliferation by repressing p21 expression.
Pathol Res Pract. 2019 Jun;215(6):152374. doi: 10.1016/j.prp.2019.03.003. Epub 2019 Mar 4.
引用本文的文献
1
Unraveling the influence of LncRNA in gastric cancer pathogenesis: a comprehensive review focus on signaling pathways interplay.
Med Oncol. 2024 Aug 5;41(9):218. doi: 10.1007/s12032-024-02455-w.
2
EZH2-interacting lncRNAs contribute to gastric tumorigenesis; a review on the mechanisms of action.
Mol Biol Rep. 2024 Feb 23;51(1):334. doi: 10.1007/s11033-024-09237-7.
3
The Effect of Race/Ethnicity and MED12 Mutation on the Expression of Long Non-Coding RNAs in Uterine Leiomyoma and Myometrium.
Int J Mol Sci. 2024 Jan 21;25(2):1307. doi: 10.3390/ijms25021307.
4
LincRNAs and snoRNAs in Breast Cancer Cell Metastasis: The Unknown Players.
Cancers (Basel). 2022 Sep 19;14(18):4528. doi: 10.3390/cancers14184528.
5
LncRNA : A Promising Biomarker and Therapeutic Target in Human Cancers.
Front Cell Dev Biol. 2022 Jan 20;10:785030. doi: 10.3389/fcell.2022.785030. eCollection 2022.
6
LncRNA LINC00337 sponges mir-1285-3p to promote proliferation and metastasis of lung adenocarcinoma cells by upregulating YTHDF1.
Cancer Cell Int. 2021 Oct 18;21(1):550. doi: 10.1186/s12935-021-02253-8.
7
Upregulation of LINC00659 expression predicts a poor prognosis and promotes migration and invasion of gastric cancer cells.
Oncol Lett. 2021 Jul;22(1):557. doi: 10.3892/ol.2021.12818. Epub 2021 May 24.
8
ZEB1-induced LINC01559 expedites cell proliferation, migration and EMT process in gastric cancer through recruiting IGF2BP2 to stabilize ZEB1 expression.
Cell Death Dis. 2021 Apr 6;12(4):349. doi: 10.1038/s41419-021-03571-5.
9
Autophagy and gastrointestinal cancers: the behind the scenes role of long non-coding RNAs in initiation, progression, and treatment resistance.
Cancer Gene Ther. 2021 Dec;28(12):1229-1255. doi: 10.1038/s41417-020-00272-7. Epub 2021 Jan 11.
10
LINC00337 promotes tumor angiogenesis in colorectal cancer by recruiting DNMT1, which suppresses the expression of CNN1.
Cancer Gene Ther. 2021 Dec;28(12):1285-1297. doi: 10.1038/s41417-020-00277-2. Epub 2020 Dec 16.
本文引用的文献
1
SNHG20: A vital lncRNA in multiple human cancers.
J Cell Physiol. 2019 Sep;234(9):14519-14525. doi: 10.1002/jcp.28143. Epub 2019 Jan 15.
2
Prognostic Value of Long Noncoding RNAs in Patients with Gastrointestinal Cancer: A Systematic Review and Meta-Analysis.
Dis Markers. 2018 Nov 26;2018:5340894. doi: 10.1155/2018/5340894. eCollection 2018.
3
Endoscopic submucosal dissection of papillary adenocarcinoma of stomach; protocol for a systematic review and meta-analysis.
Medicine (Baltimore). 2018 Dec;97(52):e13905. doi: 10.1097/MD.0000000000013905.
4
MALAT1: a potential biomarker in cancer.
Cancer Manag Res. 2018 Dec 6;10:6757-6768. doi: 10.2147/CMAR.S169406. eCollection 2018.
5
Gastric adenocarcinoma and proximal polyposis of the stomach: diagnosis and clinical perspectives.
Clin Exp Gastroenterol. 2018 Dec 3;11:447-459. doi: 10.2147/CEG.S163227. eCollection 2018.
6
Non-Coding RNAs in Glioma.
Cancers (Basel). 2018 Dec 22;11(1):17. doi: 10.3390/cancers11010017.
7
Simulation Models in Gastric Cancer Screening: A Systematic Review.
Asian Pac J Cancer Prev. 2018 Dec 25;19(12):3321-3334. doi: 10.31557/APJCP.2018.19.12.3321.
8
A Review on Theragnostic Applications of Micrornas and Long Non- Coding RNAs in Colorectal Cancer.
Curr Top Med Chem. 2018;18(30):2614-2629. doi: 10.2174/1568026619666181221165344.
9
Chinese consensus on management of tyrosine kinase inhibitor-associated side effects in gastrointestinal stromal tumors.
World J Gastroenterol. 2018 Dec 14;24(46):5189-5202. doi: 10.3748/wjg.v24.i46.5189.
10
Long noncoding RNA LINC-PINT is inhibited in gastric cancer and predicts poor survival.
J Cell Biochem. 2019 Jun;120(6):9594-9600. doi: 10.1002/jcb.28236. Epub 2018 Dec 19.
Zotero 插件