长链非编码RNA LINC00337通过抑制EZH2介导的p21来促进胃癌增殖。
Long noncoding RNA LINC00337 promote gastric cancer proliferation through repressing p21 mediated by EZH2.
作者信息
Hu Bo, Wang Xiaoye, Li Long
机构信息
Department of Pediatric Surgery, Tianjin Medical University General Hospital Tianjin, China.
Department of General surgery, Capital Institute of Pediatrics Children's Hospital Beijing, China.
出版信息
Am J Transl Res. 2019 May 15;11(5):3238-3245. eCollection 2019.
Abstract
Gastric cancer is one of the most common human malignancies. Some long noncoding RNA (lncRNA) has been validated to be oncogene in gastric cancer. In this research, we found that LINC00337 was up-regulated in the gastric cancer cells and tissue specimens. Clinically, the ectopic LINC00337 overexpression indicates the poor clinical outcome. The functional experiments illustrated that LINC00337 silencing repressed the proliferation, invasion and tumor growth in vitro and in vivo. The mechanical experiments showed that LINC00337 epigenetically repressed the p21 via EZH2-mediated inhibition. Overall, this finding suggests that LINC00337 acts as the oncogene to promote gastric cancer cells proliferation through epigenetically repressing p21 mediated by EZH2, providing a new insight for gastric cancer.
摘要
胃癌是人类最常见的恶性肿瘤之一。一些长链非编码RNA（lncRNA）已被证实为胃癌中的癌基因。在本研究中，我们发现LINC00337在胃癌细胞和组织标本中表达上调。临床上，异位LINC00337过表达提示临床预后不良。功能实验表明，LINC00337沉默在体外和体内均抑制了细胞增殖、侵袭及肿瘤生长。机制实验表明，LINC00337通过EZH2介导的抑制作用对p21进行表观遗传抑制。总体而言，这一发现表明LINC00337作为癌基因，通过EZH2介导的对p21的表观遗传抑制作用促进胃癌细胞增殖，为胃癌研究提供了新的见解。
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