Division of Clinical Neurology, University of Nottingham, Queen's Medical Centre, UK.
Mult Scler. 2011 Nov;17(11):1313-23. doi: 10.1177/1352458511415305. Epub 2011 Jul 25.
The 'normal appearing white matter' (NAWM) in multiple sclerosis (MS) is known to be abnormal using quantitative magnetic resonance (MR) techniques. The aetiology of the changes in NAWM remains debatable.
To investigate whether high-field and ultra high-field T(1)-weighted magnetization prepared rapid acquisition gradient echo (MPRAGE) MRI enables detection of MS white matter lesions in areas defined as NAWM using high-field T(2)-weighted fluid attenuation inversion recovery (FLAIR) MRI; that is, to ascertain whether undetected lesions are likely contributors to the burden of abnormality in similarly defined NAWM.
Fourteen MS patients underwent MRI scans using 3T FLAIR and MPRAGE and 7 Tesla (7T) MPRAGE sequences. Independent observers identified lesions on 3T FLAIR and (7T and 3T) MPRAGE images. The detection of every individual lesion was then compared for each image type.
We identified a total of 812 white matter lesions on 3T FLAIR. Using 3T MPRAGE, 186 additional lesions were detected that were not detected using 3T FLAIR. Using 7T MPRAGE, 231 additional lesions were detected that were not detected using 3T FLAIR.
MRI with 3T and 7T MPRAGE enables detection of MS lesions in areas defined as NAWM using 3T FLAIR. Focal MS lesions contribute to the abnormalities known to exist in the NAWM.
已知多发性硬化症（MS）的“正常外观白质”（NAWM）通过定量磁共振（MR）技术存在异常。NAWM 变化的病因仍存在争议。
探讨高场和超高场 T(1)-加权磁化准备快速获取梯度回波（MPRAGE）MRI 是否能够在使用高场 T(2)-加权液体衰减反转恢复（FLAIR）MRI 定义的 NAWM 区域检测到 MS 脑白质病变；也就是说，确定未检测到的病变是否可能是类似定义的 NAWM 中异常负担的主要原因。
14 例 MS 患者接受了 3T FLAIR 和 MPRAGE 以及 7 特斯拉（7T）MPRAGE 序列的 MRI 扫描。独立观察者在 3T FLAIR 和（7T 和 3T）MPRAGE 图像上识别病变。然后比较每种图像类型的每个病变的检测情况。
我们在 3T FLAIR 上共发现了 812 个脑白质病变。使用 3T MPRAGE，检测到了 186 个未在 3T FLAIR 上检测到的病变。使用 7T MPRAGE，检测到了 231 个未在 3T FLAIR 上检测到的病变。
3T 和 7T MPRAGE 的 MRI 能够在使用 3T FLAIR 定义的 NAWM 区域检测到 MS 病变。局灶性 MS 病变导致了已知存在于 NAWM 中的异常。
