Department of Ophthalmology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Department of Retinal Disease Control, Tohoku University Graduate School of Medicine, Sendai, Japan.
Sci Rep. 2019 Jun 20;9(1):8875. doi: 10.1038/s41598-019-45336-3.
This study evaluated age-related changes in the superficial and deep retinal capillary plexus (SCP and DCP, respectively) and in the foveal avascular zone (FAZ). SCP and DCP perfusion density (PD) were measured in optical coherence tomography angiography (OCTA) macular scans of 145 eyes of 145 healthy Japanese subjects, and findings were compared with SCP FAZ and clinical data. We found that age was negatively correlated with SCP and DCP PD (r = -0.17, P = 0.04 and r = -0.20, P = 0.02, respectively) and positively correlated with FAZ area (r = 0.18, P = 0.03). SCP and DCP PD were correlated with each other (r = 0.67, P < 0.001). FAZ area was negatively correlated with SCP PD, DCP PD and central macular thickness (CMT) (r = -0.18, P = 0.03; r = -0.25, P < 0.01; and r = -0.39, P < 0.001, respectively). FAZ was larger and CMT was lower (P = 0.01 and P < 0.001, respectively) in women than men. SCP and DCP PD were positively correlated with estimated glomerular filtration rate (r = 0.17, P = 0.03 and r = 0.24, P < 0.01, respectively). Multiple regression analysis confirmed that age independently affected DCP PD and FAZ (P = 0.02 and P < 0.01, respectively) and that CMT independently affected FAZ area (P < 0.001). Thus, normal subjects showed age-related decreases in macular PD and renal function. FAZ and CMT were related, suggesting that age-related changes in macular thickness also affect capillary vasculature.
本研究评估了浅层视网膜毛细血管丛（SCP）和深层视网膜毛细血管丛（DCP）以及中心无血管区（FAZ）的年龄相关性变化。对 145 名日本健康受试者的光学相干断层扫描血管造影（OCTA）黄斑扫描中的 SCP 和 DCP 灌注密度（PD）进行了测量，并将结果与 SCP FAZ 和临床数据进行了比较。我们发现，年龄与 SCP 和 DCP PD 呈负相关（r=-0.17，P=0.04 和 r=-0.20，P=0.02），与 FAZ 面积呈正相关（r=0.18，P=0.03）。SCP 和 DCP PD 相互之间存在相关性（r=0.67，P<0.001）。FAZ 面积与 SCP PD、DCP PD 和中心黄斑厚度（CMT）呈负相关（r=-0.18，P=0.03；r=-0.25，P<0.01；r=-0.39，P<0.001）。女性的 FAZ 较大，CMT 较低（P=0.01 和 P<0.001）。SCP 和 DCP PD 与估计肾小球滤过率（r=0.17，P=0.03 和 r=0.24，P<0.01）呈正相关。多元回归分析证实，年龄独立影响 DCP PD 和 FAZ（P=0.02 和 P<0.01），CMT 独立影响 FAZ 面积（P<0.001）。因此，正常受试者的黄斑 PD 和肾功能均随年龄增长而降低。FAZ 和 CMT 之间存在相关性，表明黄斑厚度的年龄相关性变化也会影响毛细血管血管。
