LKS Faculty of Medicine, University of Hong Kong, Hong Kong, China.
Department of Ophthalmology, Li Ka Shing Faculty of Medicine, School of Clinical Medicine, University of Hong Kong, Room 301, Level 3, Block B, Cyberport 4, 100 Cyberport Road, Pokfulam, Hong Kong, China.
BMC Ophthalmol. 2023 Feb 16;23(1):71. doi: 10.1186/s12886-023-02815-6.
BACKGROUND/AIMS: To assess the normative values and parameters of optical coherence tomography angiography (OCTA) influencing the best corrected visual acuity (BCVA) in adults aged 50 and above.
This was a prospective cross-sectional study from an eye screening programme in Hong Kong for 4188 citizens aged 50 and above. Images were analysed using a validated quantification software calculating vessel density and capillary perfusion density (CPD), along with other OCTA parameters, such as the foveal avascular zone area (FAZ) and circularity. OCTA data was collected from May 2019 to December 2020, including a total of 4188 healthy eyes from 4188 subjects.
Mean superficial vessel density (MSVD) was 14.48 ± 3.60 mm, while the mean capillary perfusion density (MCPD) was 0.41 ± 0.06. Multivariate analysis revealed ageing (β = 0.321, p < 0.001), being male (β=-0.089, p < 0.001), having a high body mass index (BMI) (β = 0.039, p = 0.006), high FAZ area and low FAZ circularity (β = 0.039 and - 0.034, p = 0.01 and 0.024 respectively), low MSVD in the outer ring (β=-0.513, p < 0.001), specifically in the nasal and temporal outer quadrants (β = -0.226 and - 0.259, p < 0.001 for both), and low MCPD in the outer superior quadrant (β= -0.123, p = 0.016) being independently associated with BCVA.
High FAZ area and low FAZ circularity, low MSVD in the outer ring, specifically the nasal and temporal outer quadrants, and low MCPD in the outer superior quadrant can be used as biomarkers in predicting a low visual acuity in adults aged 50 and above.
背景/目的：评估影响 50 岁及以上成年人最佳矫正视力（BCVA）的光学相干断层扫描血管造影（OCTA）的正常值和参数。
这是一项来自香港的针对 50 岁及以上公民的眼部筛查计划的前瞻性横断面研究。使用经过验证的量化软件分析图像，计算血管密度和毛细血管灌注密度（CPD），以及其他 OCTA 参数，如中央无血管区面积（FAZ）和圆度。OCTA 数据于 2019 年 5 月至 2020 年 12 月采集，共纳入 4188 名受试者的 4188 只健康眼。
平均浅层血管密度（MSVD）为 14.48±3.60mm，平均毛细血管灌注密度（MCPD）为 0.41±0.06。多变量分析显示，年龄增长（β=0.321，p<0.001）、男性（β=-0.089，p<0.001）、高体质指数（BMI）（β=0.039，p=0.006）、大 FAZ 面积和低 FAZ 圆度（β=0.039 和 -0.034，p=0.01 和 0.024 分别）、外环 MSVD 低（β=-0.513，p<0.001），特别是鼻侧和颞侧外环（β=-0.226 和 -0.259，p<0.001）和外环上象限 MCPD 低（β=-0.123，p=0.016）与 BCVA 独立相关。
大 FAZ 面积和低 FAZ 圆度、外环 MSVD 低，特别是鼻侧和颞侧外环，以及外环上象限 MCPD 低可作为预测 50 岁及以上成年人低视力的生物标志物。
