Department of Plastic and Aesthetic Surgery, Nanfang Hospital of Southern Medical University, 1838 North Guangzhou AV, Guangzhou, 510515, Guangdong Province, China.
Clin Drug Investig. 2019 Sep;39(9):865-872. doi: 10.1007/s40261-019-00806-4.
Platelet-rich plasma (PRP) has received growing attention as a valuable therapeutic tool in androgenetic alopecia (AGA). However, knowledge regarding specific effectiveness and satisfaction of PRP for different grades of AGA in male pattern hair loss (MPHL) and female pattern hair loss (FPHL) is missing. This study aims to ascertain and compare the efficacy and safety of PRP treatment for different grades of AGA in males and females over 6 months.
In this study, 51 MPHL patients with Norwood-Hamilton stage II-V and 42 FPHL patients with Ludwig stage I to III were enrolled for 6 monthly sessions of PRP injections. A longitudinal analysis was used to compare the hair density, thickness, and hair pull test over 6 months for MPHL and FPHL through generalized estimating equation (GEE) models. Phototrichograms of scalp inflammation and oil secretion, global photographs and overall patient satisfaction were also assessed.
Consequently, improvement of hair density, hair thickness, hair pull test, the level of scalp inflammation and oil secretion were observed with statistical significance in all stages for both MPHL and FPHL at 6 months. Noteworthy, lower level of alopecia (Grade II, III in MPHL and Grade I in FPHL) had better response to PRP, and also had a better tendency of increment of hair growth than that of high-grade patients with prolonged treatment.
PRP injections, as an efficacious and reliable therapy, can be recommended for Grade II and Grade III in MPHL and Grade I in FPHL.
富含血小板的血浆（PRP）作为一种有价值的治疗工具，在雄激素性脱发（AGA）中受到越来越多的关注。然而，对于男性型脱发（MPHL）和女性型脱发（FPHL）中不同等级的 AGA，PRP 的具体有效性和满意度的知识尚不清楚。本研究旨在确定和比较 PRP 治疗男性和女性不同等级 AGA 的疗效和安全性，随访时间为 6 个月。
本研究纳入了 51 例 Norwood-Hamilton 分级 II-V 期的 MPHL 患者和 42 例 Ludwig 分级 I 至 III 期的 FPHL 患者，进行 6 个月的 PRP 注射。通过广义估计方程（GEE）模型对 MPHL 和 FPHL 进行纵向分析，比较 6 个月时的毛发密度、厚度和毛发牵拉试验。还评估了头皮炎症和油脂分泌的毛发图、整体照片和整体患者满意度。
结果显示，在 6 个月时，所有 MPHL 和 FPHL 阶段的毛发密度、毛发厚度、毛发牵拉试验、头皮炎症和油脂分泌水平均有显著改善。值得注意的是，低等级的脱发（MPHL 的 II 级和 III 级，FPHL 的 I 级）对 PRP 的反应更好，并且与高等级患者相比，其毛发增长的趋势更好，需要延长治疗时间。
PRP 注射作为一种有效且可靠的治疗方法，可推荐用于 MPHL 的 II 级和 III 级以及 FPHL 的 I 级。
