Student Research Committee, School of Nutrition & Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
Research Center of Psychiatry & Behavioral Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
Nutr Neurosci. 2021 May;24(5):339-353. doi: 10.1080/1028415X.2019.1630985. Epub 2019 Jun 26.
Major depressive disorder (MDD) is a common psychiatric disorder, closely associated with obesity. This study aimed to assess the effects of prebiotics combined with calorie restriction on clinical and metabolic response in obese women with MDD.
In an 8-week double-blind placebo-controlled randomized clinical trial, 62 obese women with MDD were equally allocated into either prebiotic (10 g/day Inulin) or placebo (10 g/day Maltodextrin) group. In addition, all the participants were also prescribed a 25% calorie-restricted diet (registration ID: IRCT20100209003320N15). Depression was assessed by Hamilton depression rating scale (HDRS) and Beck depression inventory (BDI-II) pre- and post-intervention. Anthropometric measures, fasting serum levels of glucose, insulin and lipid profile were assessed, and dietary assessments were performed pre- and post-intervention. Insulin resistance was estimated by homeostasis model assessment of insulin resistance (HOMA-IR).
45 patients completed the trial. There were no significant between-group differences for MDD symptoms and other study outcomes, post-intervention. Weight, waist and hip circumferences, systolic blood pressure, and HDRS score significantly decreased in both groups, while fat mass and total cholesterol (TC) declined only in the prebiotic arm. Those who had ≥1.9 kg weight loss showed significantly improved HDRS score, compared to women with <1.9 kg weight reduction, irrespective of the supplement they took.
Although prebiotic supplementation had some beneficial metabolic effects, calorie restriction and weight loss seem to play a more important role in improving depressive symptoms among obese women with MDD.
重度抑郁症（MDD）是一种常见的精神疾病，与肥胖密切相关。本研究旨在评估益生元联合热量限制对肥胖伴 MDD 女性的临床和代谢反应的影响。
在一项为期 8 周的双盲安慰剂对照随机临床试验中，将 62 名肥胖伴 MDD 的女性平均分为益生元（每天 10g 菊粉）或安慰剂（每天 10g 麦芽糊精）组。此外，所有参与者还接受了 25%热量限制饮食（注册号：IRCT20100209003320N15）。在干预前后使用汉密尔顿抑郁量表（HDRS）和贝克抑郁自评量表（BDI-II）评估抑郁情况。评估干预前后的人体测量学指标、空腹血糖、胰岛素和血脂水平，并进行饮食评估。使用稳态模型评估胰岛素抵抗（HOMA-IR）评估胰岛素抵抗。
45 名患者完成了试验。干预后，两组 MDD 症状和其他研究结果均无显著差异。两组体重、腰围和臀围、收缩压和 HDRS 评分均显著降低，而益生元组的脂肪量和总胆固醇（TC）下降。与体重减轻<1.9kg 的女性相比，体重减轻≥1.9kg 的女性 HDRS 评分显著改善，无论她们服用哪种补充剂。
虽然益生元补充剂有一些有益的代谢作用，但热量限制和体重减轻似乎在改善肥胖伴 MDD 女性的抑郁症状方面发挥着更重要的作用。
