铜催化的烯烃光诱导对映选择性双碳官能化反应
Copper-Catalyzed Photoinduced Enantioselective Dual Carbofunctionalization of Alkenes.
作者信息
Zhang Yajing, Sun Youwen, Chen Bin, Xu Meichen, Li Chen, Zhang Dayong, Zhang Guozhu
机构信息
Institute of Pharmaceutical Science , China Pharmaceutical University , Nanjing 210009 , China.
State Key Laboratory of Organometallic Chemistry , Shanghai Institute of Organic Chemistry, Center for Excellence in Molecular Synthesis, University of Chinese Academy of Sciences, Chinese Academy of Sciences , 345 Lingling Road , Shanghai 200032 , P. R. China.
出版信息
Org Lett. 2020 Feb 21;22(4):1490-1494. doi: 10.1021/acs.orglett.0c00071. Epub 2020 Feb 6.
A photoinduced, copper-catalyzed, highly enantioselective dual alkylation/arylation and alkynylation of alkene is reported. A single chiral copper(I) complex serves to enable photoredox catalysis and induce enantioselectivity during the reaction. This reaction couples three different components under mild reaction conditions, exhibits a broad substrate scope, and provides facile access to chiral propargylic systems, including those featuring valuable fluorinated substituents.
报道了一种光诱导、铜催化的烯烃高度对映选择性双烷基化/芳基化和炔基化反应。单一手性铜（I）配合物用于实现光氧化还原催化并在反应过程中诱导对映选择性。该反应在温和的反应条件下将三种不同的组分偶联起来，具有广泛的底物范围，并能方便地合成手性炔丙基体系，包括那些含有有价值的氟取代基的体系。
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