School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei 11031, Taiwan.
Orthodontic Division, Department of Dentistry, Taipei Medical University Hospital, Taipei 11031, Taiwan.
Int J Environ Res Public Health. 2019 Jun 25;16(12):2243. doi: 10.3390/ijerph16122243.
Plaque accumulation and white spot lesions are common adverse effects of fixed orthodontic appliance use. This study compared the effects between enzyme-containing and conventional dentifrices on orthodontic patients. This double-blind randomized controlled trial included 42 orthodontic patients (25 women and 17 men: 22.7 ± 4.2 years) from Taipei Medical University Hospital between 2017 and 2018. The patients were randomly divided into three groups and assigned to dentifrice use during the first 3 months of the orthodontic treatment: group 1 used dentifrices containing enzymes including amyloglucosidase and glucose oxidase, group 2 used dentifrices containing 1450 ppm fluoride, and group 3 used natural dentifrices containing no chemical agent. White spot lesion index (WSL), gingival bleeding index (GBI), and visible plaque index (VPI) were recorded and analyzed. WSL, GBI, and VPI values exhibited no significant difference among the three groups. WSL increased significantly in group 3, GBI decreased significantly in all groups, and VPI decreased significantly in groups 1 and 2. No significant difference was observed between the use of enzyme-containing and conventional dentifrices after fixed orthodontic appliance placement.
斑块积累和白色斑点病变是固定正畸装置使用的常见不良反应。本研究比较了含酶牙膏和传统牙膏对正畸患者的影响。这项双盲随机对照试验纳入了 2017 年至 2018 年间来自台北医学大学附属医院的 42 名正畸患者（25 名女性和 17 名男性：22.7±4.2 岁）。患者被随机分为三组，并在正畸治疗的前 3 个月内分配使用牙膏：第 1 组使用含有淀粉酶和葡萄糖氧化酶的含酶牙膏，第 2 组使用含有 1450ppm 氟化物的牙膏，第 3 组使用不含化学物质的天然牙膏。记录和分析白色斑点指数（WSL）、牙龈出血指数（GBI）和可见菌斑指数（VPI）。三组之间的 WSL、GBI 和 VPI 值均无显著差异。第 3 组的 WSL 显著增加，所有组的 GBI 显著降低，第 1 组和第 2 组的 VPI 显著降低。固定正畸装置放置后，使用含酶牙膏和传统牙膏之间没有观察到显著差异。
