Department of Ophthalmology, Tokyo Medical University, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo, 160-0023, Japan.
Department of Dermatology, Tokyo Medical University, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo, 160-0023, Japan.
Jpn J Ophthalmol. 2019 Sep;63(5):410-416. doi: 10.1007/s10384-019-00678-3. Epub 2019 Jun 26.
To elucidate the recent trends in prevalence and characteristics of ocular complications of atopic dermatitis (AD).
Cross-sectional observational study.
Among AD patients who visited our department between 2012 and 2015, 70 patients (140 eyes; recent AD group) who gave informed consent to participate in the study were analyzed. Following a medical interview, ophthalmological examinations were conducted for ocular complications related to AD. The data were compared to those of 280 AD patients (560 eyes) analyzed in a similar study conducted at our department in 1991-1993 (previous AD group).
Blepharitis was found in 58 eyes (41%) in the recent AD group, and the frequency was significantly lower compared to the previous AD group (294 eyes, 53%) (p < 0.05). Tears in retina or pars plana ciliaris occurred in 22 eyes (4%) in the previous AD group, compared with none in the recent AD group (p < 0.01). Retinal detachment was observed in 12 eyes (2%) in the previous AD group, and none in the recent AD group (p < 0.01). Atopic keratoconjunctivitis (AKC) increased significantly in the recent AD group compared to the previous AD group (74.3% vs. 39.5%) (p < 0.001). Patients with a habit of slapping around the eye decreased significantly from 32.5% in the previous AD group to 12.1% in the recent AD group (p < 0.001).
Ocular complications in AD patients show a trend of decrease in recent years, which presumably is attributed to educational activities to increase patient awareness and advances in therapeutic strategy.
阐明特应性皮炎（AD）眼部并发症的最新流行趋势和特征。
横断面观察性研究。
在 2012 年至 2015 年间就诊于我科的 AD 患者中，选取 70 例（140 只眼；近期 AD 组），并对其进行眼部并发症的检查。在进行医学访谈后，对与 AD 相关的眼部并发症进行眼科检查。并将这些数据与 1991-1993 年在我科进行的类似研究中的 280 例 AD 患者（560 只眼；既往 AD 组）的数据进行比较。
在近期 AD 组中，58 只眼（41%）患有睑缘炎，其发生率明显低于既往 AD 组（294 只眼，53%）（p<0.05）。既往 AD 组中有 22 只眼（4%）出现视网膜或睫状体扁平部视网膜脱离，而近期 AD 组中无此情况（p<0.01）。既往 AD 组中有 12 只眼（2%）出现视网膜脱离，而近期 AD 组中无此情况（p<0.01）。近期 AD 组的特应性角结膜炎（AKC）明显增多，与既往 AD 组相比（74.3%比 39.5%）（p<0.001）。有拍打眼部习惯的患者明显减少，从既往 AD 组的 32.5%降至近期 AD 组的 12.1%（p<0.001）。
近年来 AD 患者的眼部并发症呈下降趋势，这可能归因于提高患者意识的教育活动和治疗策略的进步。
