State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering , Hunan University , Changsha , Hunan 410082 , China.
Molecular Imaging Program at Stanford, Department of Radiology , Stanford University School of Medicine , 1201 Welch Road , Stanford , California 94305-5484 , United States.
ACS Nano. 2019 Jul 23;13(7):7750-7758. doi: 10.1021/acsnano.9b01436. Epub 2019 Jun 20.
Multimodality imaging involves the use of more imaging modes to image the same living subjects and is now generally preferred in clinics for cancer imaging. Here we present multimodality-Magnetic Particle Imaging (MPI), Magnetic Resonance Imaging (MRI), Photoacoustic, Fluorescent-nanoparticles (termed MMPF NPs) for imaging tumor xenografts in living mice. MMPF NPs provide long-term (more than 2 months), dynamic, and accurate quantification, , of NPs and in real time by MPI. Moreover, MMPF NPs offer ultrasensitive MPI imaging of tumors (the tumor ROI increased by 30.6 times over that of preinjection). Moreover, the nanoparticle possessed a long-term blood circulation time (half-life at 49 h) and high tumor uptake (18% ID/g). MMPF NPs have been demonstrated for imaging breast and brain tumor xenografts in both subcutaneous and orthotopic models in mice via simultaneous MPI, MRI, fluorescence, and photoacoustic imaging with excellent tumor contrast to normal tissues.
多模态成像是指使用多种成像模式对同一活体进行成像，目前在癌症成像的临床应用中普遍受到青睐。在这里，我们提出了多模态-磁性粒子成像（MPI）、磁共振成像（MRI）、光声、荧光纳米粒子（称为 MMPF NPs），用于活体小鼠肿瘤异种移植的成像。MMPF NPs 提供了长期（超过 2 个月）、动态和准确的 NPs 定量，通过 MPI 实时进行。此外，MMPF NPs 还提供了肿瘤的超灵敏 MPI 成像（肿瘤 ROI 比注射前增加了 30.6 倍）。此外，该纳米颗粒具有较长的血液循环时间（半衰期为 49 小时）和高肿瘤摄取率（18% ID/g）。MMPF NPs 已通过 MPI、MRI、荧光和光声成像在小鼠的皮下和原位模型中进行了乳腺癌和脑肿瘤异种移植的成像，具有优异的肿瘤与正常组织的对比。
