Molecular Imaging Program at Stanford, Department of Radiology, Stanford University School of Medicine , 1201 Welch Road, Stanford, California 94305-5484, United States.
Department of Radiology, Neuroimaging and Neurointervention Division, Stanford University Hospital , 300 Pasteur Drive, Stanford, California 94305, United States.
Nano Lett. 2018 Jan 10;18(1):182-189. doi: 10.1021/acs.nanolett.7b03829. Epub 2017 Dec 15.
Iron oxides nanoparticles tailored for magnetic particle imaging (MPI) have been synthesized, and their MPI signal intensity is three-times that of commercial MPI contrast (Ferucarbotran, also called Vivotrax) and seven-times that of MRI contrast (Feraheme) at the same Fe concentration. MPI tailored iron oxide nanoparticles were encapsulated with semiconducting polymers to produce Janus nanoparticles that possessed optical and magnetic properties for MPI and fluorescence imaging. Janus particles were applied to cancer cell labeling and in vivo tracking, and as few as 250 cells were imaged by MPI after implantation, corresponding to an amount of 7.8 ng of Fe. Comparison with MRI and fluorescence imaging further demonstrated the advantages of our Janus particles for MPI-super sensitivity, unlimited tissue penetration, and linear quantitativity.
已合成用于磁粒子成像（MPI）的定制氧化铁纳米粒子，其 MPI 信号强度是商用 MPI 对比剂（Ferucarbotran，也称为 Vivotrax）的 3 倍，是 MRI 对比剂（Feraheme）的 7 倍，在相同的铁浓度下。将 MPI 定制氧化铁纳米粒子包封在半导体聚合物中，以产生具有 MPI 和荧光成像光学和磁性的 Janus 纳米粒子。Janus 颗粒被应用于癌细胞标记和体内跟踪，在植入后仅通过 MPI 即可成像 250 个细胞，相当于 7.8ng 的 Fe。与 MRI 和荧光成像的比较进一步证明了我们的 Janus 粒子在 MPI 超灵敏度、无限组织穿透性和线性定量方面的优势。
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