Graduate School of Pharmaceutical Sciences, College of Pharmacy, Ewha Womans University, Seoul 03760, Republic of Korea.
Department of Pharmacy, College of Pharmacy, Pusan National University, Busan 46241, Republic of Korea.
Molecules. 2023 Mar 13;28(6):2602. doi: 10.3390/molecules28062602.
A new bicyclic nonene, tsaokoic acid (), was isolated from the fruits of , together with three known compounds (-). The structure of was elucidated by analyzing spectroscopic data including 1D and 2D NMR spectra and compounds - were identified as tsaokoin, vanillin, and tsaokoarylone, respectively, by comparing their NMR spectra with previously reported data. Compounds - showed possible inhibitory activity against acetylcholinesterase (AChE) in silico molecular docking simulations. They were submitted to in vitro assay system and exhibited moderate inhibitory activity with IC values of 32.78, 41.70, 39.25, and 31.13 μM, respectively.
一种新的二环非壬酸（）从阳春砂的果实中分离得到，此外还分离到三种已知化合物（-）。通过分析包括 1D 和 2D NMR 光谱在内的光谱数据，阐明了的结构，并通过将其 NMR 光谱与先前报道的数据进行比较，分别鉴定为阳春砂酸、香草醛和阳春砂芳酮。化合物 - 在计算机分子对接模拟中显示出对乙酰胆碱酯酶（AChE）的可能抑制活性。它们被提交给体外测定系统，并表现出中等抑制活性，IC 值分别为 32.78、41.70、39.25 和 31.13 μM。
