Research Center for Marine Drugs, State Key Laboratory of Oncogene and Related Genes, Ren Ji Hospital, School of Medicine , Shanghai Jiao Tong University , Shanghai , 200127 , China.
Biotech Research Institute , Shanghai Academy of Agricultural Sciences, Shanghai Key Laboratory of Agricultural Genetics and Breeding , Shanghai , 201106 , China.
Org Lett. 2019 Aug 16;21(16):6190-6193. doi: 10.1021/acs.orglett.9b01754. Epub 2019 Jun 27.
The chemical investigation of the marine sponge discovered a pair of unprecedented bioconjugates that are composed of a meroterpene and an unusual psammaplysin alkaloid. The structures of frondoplysins A () and B () were characterized by analysis of HRMS and NMR data coupled with single-crystal X-ray diffraction. Frondoplysin A was found to be a potent inhibitor targeting protein-tyrosine phosphatase 1B (PTP1B) with an IC value of 0.39 μM.
从海洋海绵中发现的化学研究一对前所未有的生物缀合物，由一个混合萜和一个不寻常的沙巴菌素生物碱组成。frondoplysins A()和 B()的结构通过分析 HRMS 和 NMR 数据以及单晶 X 射线衍射来确定。frondoplysin A 被发现是一种针对蛋白酪氨酸磷酸酶 1B(PTP1B)的有效抑制剂，IC 值为 0.39 μM。
