Department of Oral Medicine & Radiology, Government Dental College & Hospital, Nagpur, Maharashtra, India.
Department of Dentistry, Indira Gandhi Government Medical College & Hospital, Nagpur, Maharashtra State, India.
PLoS One. 2019 Jun 27;14(6):e0218833. doi: 10.1371/journal.pone.0218833. eCollection 2019.
Oral cancer (OC) is one of the common malignant neoplasm resulting in a range of debilitating symptoms. Patient reported outcome measures (PROMs) could provide a valuable insight into the impact of OC on patients' quality of life (QoL). Selecting an adequate instrument among available PROMs for OC has been challenging for clinicians due to lack of information on their psychometric quality. This systematic review provides an extensive overview of methodological quality of all currently available PROMs for OC.
A systematic search was performed in PubMed, Scopus, Web of Science and CINAHL for relevant literature until 10th January 2019 and data was extracted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The quality of the identified studies was assessed per measurement property according to the COnsensus-based Standards for the selection of health Measurements Instruments (COSMIN) checklist.
Seven studies were found evaluating 6 health-related QoL PROMs. Among six, there were 1 disease-specific and 5 generic PROMs. Information regarding important measurement properties was often incomplete. The evidence for the quality of measurement properties was found to be variable, none of the instruments performed sufficient on all measurement properties. Considering results of this review, QOL-OC appeared to have adequate COSMIN measurement properties.
QOL-OC can be implemented in future studies to better understand symptoms and expectations of OC patients and help inform clinicians to formulate treatment strategies as per patients' needs.
口腔癌（OC）是常见的恶性肿瘤之一，会导致一系列使人虚弱的症状。患者报告的结局测量（PROMs）可以为了解 OC 对患者生活质量（QoL）的影响提供有价值的见解。由于缺乏有关其心理测量质量的信息，临床医生在选择 OC 可用的 PROM 中合适的工具方面一直具有挑战性。本系统评价全面概述了目前所有 OC 的 PROM 的心理测量质量。
我们在 PubMed、Scopus、Web of Science 和 CINAHL 中进行了系统搜索，以查找相关文献，检索时间截至 2019 年 1 月 10 日，并根据系统评价和荟萃分析的首选报告项目（PRISMA）指南提取数据。根据共识基础的健康测量仪器选择标准（COSMIN）清单，按照测量特性对确定研究的质量进行评估。
我们发现了 7 项评估 6 种与健康相关的 QoL PROM 的研究。其中 6 项中有 1 项疾病特异性和 5 项通用 PROM。有关重要测量特性的信息通常不完整。测量特性质量的证据发现是可变的，没有一种仪器在所有测量特性上表现都足够好。考虑到本综述的结果，QOL-OC 似乎具有足够的 COSMIN 测量特性。
QOL-OC 可以在未来的研究中实施，以更好地了解 OC 患者的症状和期望，并帮助临床医生根据患者的需求制定治疗策略。
