Fragasso Alessio, Pud Sergii, Dekker Cees
Department of Bionanoscience, Kavli Institute of Nanoscience, Delft University of Technology, Van der Maasweg 9, 2629 HZ Delft, The Netherlands.
Nanotechnology. 2019 Sep 27;30(39):395202. doi: 10.1088/1361-6528/ab2d35. Epub 2019 Jun 27.
The performance of solid-state nanopores as promising biosensors is severely hampered by low-frequency 1/f noise in the through-pore ionic current recordings. Here, we develop a model for the 1/f noise in such nanopores, that, unlike previous reports, accounts for contributions from both the pore-cylinder, pore-surface, and access regions. To test our model, we present measurements of the open-pore current noise through solid-state nanopores of different diameters (1-50 nm). To describe the observed trends, it appears essential to include the access resistance in the modeling of the 1/f noise. We attribute a different Hooge constant for the charge carrier fluctuations occurring in the bulk electrolyte and at the pore surface. The model reported here can be used to accurately analyze different contributions to the nanopore low-frequency noise, rendering it a powerful tool for characterizing and comparing different membrane materials in terms of their 1/f noise properties.
固态纳米孔作为一种很有前景的生物传感器，其在通过孔的离子电流记录中的低频1/f噪声严重阻碍了其性能。在此，我们针对此类纳米孔中的1/f噪声开发了一个模型，与之前的报告不同，该模型考虑了孔圆柱体、孔表面和接入区域的贡献。为了测试我们的模型，我们展示了通过不同直径（1 - 50纳米）的固态纳米孔的开孔电流噪声测量结果。为了描述观察到的趋势，在1/f噪声建模中纳入接入电阻似乎至关重要。我们为在本体电解质和孔表面发生的电荷载流子波动赋予了不同的霍格常数。这里报道的模型可用于准确分析对纳米孔低频噪声的不同贡献，使其成为根据1/f噪声特性表征和比较不同膜材料的有力工具。
