Ecology Department, Faculty of Sciences, Malaga University, Campus de Teatinos s/n, CP 29071, Malaga, Spain.
Biochemistry Department, Faculty of Sciences, Malaga University, Campus de Teatinos s/n, CP 29071, Malaga, Spain.
Mar Biotechnol (NY). 2019 Aug;21(4):577-587. doi: 10.1007/s10126-019-09905-x. Epub 2019 Jun 27.
Seaweeds of the genera Laminaria, Gelidium, and Porphyra have been used in both food and non-food industries due to their unique properties and characteristic biological activity. This study assesses the antioxidant activity and immunomodulatory properties of the acidic polysaccharides extracted from Laminaria ochroleuca, Porphyra umbilicalis, and Gelidium corneum collected in the Atlantic coast of Tarifa (Cadiz, Spain). The proliferation of murine cell line RAW 264 decreased with increasing concentration of polysaccharides of the three algal species. The highest both antioxidant (25.69 μmol TE g DW) and immunomodulatory activities were observed in the sulfated polysaccharides of L. ochroleuca compared to that of P. umbilicalis and G. corneum. Sulfated polysaccharides of L. ochroleuca presented high potential anticancer activity in cell lines of human colon cancer HTC-116 (IC = 0.44 mg mL), human malignant melanoma G-361 (IC = 5.42 mg mL), breast adenocarcinoma human MCF-7 (IC = 8.32 mg mL), and human leukemia U-937 (IC = 3.72 mg mL). It is concluded that metabolites of L. ochroleuca can offer significant advantages for the pharmaceutical industry, particularly when macrophage activation is required.
由于其独特的性质和特征生物活性，海带、麒麟菜和石花菜属海藻已被应用于食品和非食品工业。本研究评估了从西班牙加的斯塔里法（Tarifa）大西洋沿岸采集的海带、紫菜和角叉菜中提取的酸性多糖的抗氧化活性和免疫调节特性。三种海藻的多糖浓度越高，鼠源细胞系 RAW 264 的增殖越低。与紫菜和角叉菜相比，海带的硫酸化多糖具有最高的抗氧化（25.69 μmol TE g DW）和免疫调节活性。海带的硫酸化多糖在人结肠癌细胞 HTC-116（IC = 0.44 mg mL）、人恶性黑色素瘤 G-361（IC = 5.42 mg mL）、人乳腺癌 MCF-7（IC = 8.32 mg mL）和人白血病 U-937（IC = 3.72 mg mL）细胞系中表现出高的潜在抗癌活性。综上所述，海带的代谢产物可为制药工业带来显著优势，特别是在需要激活巨噬细胞时。
