患有和未患有共病注意力缺陷多动障碍的成年双相情感障碍患者的神经心理学概况。
Neuropsychological profiles of adult bipolar disorder patients with and without comorbid attention-deficit hyperactivity disorder.
作者信息
Salarvan Sara, Sparding Timea, Clements Caitlin, Rydén Eleonore, Landén Mikael
机构信息
Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Sahlgrenska University Hospital, Blå Stråket 15, 413 45, Gothenburg, Sweden.
Department of Psychology, University of Pennsylvania, 3720 Walnut Street, Philadelphia, PA, 19104, USA.
出版信息
Int J Bipolar Disord. 2019 Jun 28;7(1):14. doi: 10.1186/s40345-019-0149-9.
BACKGROUND
Comorbid attention-deficit/hyperactivity disorder (ADHD) is common in bipolar disorder and associated with worse outcomes. Cognitive testing might be a tool to identify this group. Here we compare the neuropsychological profiles of bipolar disorder patients with (BD + cADHD) and without (BD - cADHD) childhood attention-deficit hyperactivity disorder.
METHODS
Adult patients with BD - cADHD (n = 66), BD + cADHD (n = 32), and healthy controls (n = 112) were tested using a comprehensive battery of neuropsychological tests. Patients underwent rigorous diagnostic assessments for bipolar disorder and ADHD, as well as a parental interview to establish childhood ADHD.
RESULTS
The neuropsychological profiles of the groups were similar, except that the BD + cADHD group performed significantly worse on working memory. Working memory did not differ between those in the BD + cADHD group who only had a history of childhood ADHD and those that still met criteria for ADHD in adulthood.
CONCLUSIONS
Cognitive testing had limited power to differentiate between bipolar disorder adults with and without childhood ADHD. The BD + cADHD subgroup cannot explain the significant cognitive heterogeneity seen in bipolar disorder patients.
背景
共病注意力缺陷多动障碍（ADHD）在双相情感障碍中很常见，且与更差的预后相关。认知测试可能是识别这一群体的一种工具。在此，我们比较了患有（BD + cADHD）和未患有（BD - cADHD）儿童期注意力缺陷多动障碍的双相情感障碍患者的神经心理学概况。
方法
使用一套全面的神经心理学测试对患有BD - cADHD（n = 66）、BD + cADHD（n = 32）的成年患者以及健康对照者（n = 112）进行测试。患者接受了针对双相情感障碍和ADHD的严格诊断评估，以及一次家长访谈以确定儿童期ADHD情况。
结果
这些组的神经心理学概况相似，只是BD + cADHD组在工作记忆方面表现明显更差。仅患有儿童期ADHD病史的BD + cADHD组患者与成年后仍符合ADHD标准的患者在工作记忆方面没有差异。
结论
认知测试在区分患有和未患有儿童期ADHD的双相情感障碍成年患者方面能力有限。BD + cADHD亚组无法解释双相情感障碍患者中显著的认知异质性。
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