“886-84 样”蜱传脑炎病毒株：通过比较基因组学阐明的种内地位。
"886-84-like" tick-borne encephalitis virus strains: Intraspecific status elucidated by comparative genomics.
机构信息
Irkutsk Anti-Plague Research Institute of Siberia and Far East, Trilisser 78, 664047, Irkutsk, Russia; Irkutsk State University, Irkutsk, Russia.
Irkutsk Anti-Plague Research Institute of Siberia and Far East, Trilisser 78, 664047, Irkutsk, Russia.
出版信息
Ticks Tick Borne Dis. 2019 Aug;10(5):1168-1172. doi: 10.1016/j.ttbdis.2019.06.006. Epub 2019 Jun 15.
Tick-borne encephalitis virus (TBEV) can cause severe meningitis, encephalitis, and meningoencephalitis. TBEV represents a pathogen of high zoonotic potential and an emerging global threat. There are three known subtypes of TBEV: Far-Eastern, Siberian and European. Since 2001 there have been suggestions that two new subtypes may be distinguished: "178-79" and "886-84". These assumptions are based on the results of the envelope gene fragment sequencing (Zlobin et al., 2001; Kovalev and Mukhacheva, 2017) and genotype-specific probes molecular hybridization (Demina et al., 2010). There is only one full-genome sequence of "178-79" strain and two identical ones of "886-84" strain can be found in GenBank. For clarification of the intraspecific position of the "886-84-like" strains group we completely sequenced six previously unknown "886-84-like" strains isolated in Eastern Siberia. As a result of applying different bioinformatics approaches, we can confirm that "886-84-like" strains group is a distinct subtype of TBEV.
蜱传脑炎病毒（TBEV）可引起严重的脑膜炎、脑炎和脑膜脑炎。TBEV 具有很高的人畜共患病潜力，是一种新出现的全球威胁。目前已知 TBEV 有三个亚型：远东型、西伯利亚型和欧洲型。自 2001 年以来，有人提出可能可以区分两种新的亚型：“178-79”和“886-84”。这些假设是基于包膜基因片段测序的结果（Zlobin 等人，2001 年；Kovalev 和 Mukhacheva，2017 年）和基因型特异性探针分子杂交（Demina 等人，2010 年）。目前只有一个“178-79”株的全基因组序列，而 GenBank 中可以找到两个相同的“886-84”株。为了澄清“886-84 样”株群的种内位置，我们对在东西伯利亚分离到的六个以前未知的“886-84 样”株进行了完全测序。通过应用不同的生物信息学方法，我们可以确认“886-84 样”株群是 TBEV 的一个独特亚型。
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