Liang Shuaishuai, Wei Jingjing, Jiang Lvqi, Liu Jie, Mumtaz Yasir, Yi Wenbin
School of Chemical Engineering, Nanjing University of Science and Technology, 200 Xiao Ling Wei Street, Nanjing 210094, China.
Chem Commun (Camb). 2019 Jul 18;55(59):8536-8539. doi: 10.1039/c9cc03282g.
A newly developed CF3SO2Na-based trifluoromethylation of secondary amines has been disclosed, and the method has been successfully extended to the configuration of perfluoroalkyl amines using RfSO2Na, complementing the established synthesis strategy of trifluoromethyl amines. Advantages of the method include good functional group tolerance, mild conditions, and inexpensive or easy-to-handle materials. Mechanistic probes indicate that the thiocarbonyl fluoride formed in situ is the key intermediate in the reaction.
一种新开发的基于CF3SO2Na的仲胺三氟甲基化反应已被公开，该方法已成功扩展到使用RfSO2Na构建全氟烷基胺，补充了已有的三氟甲基胺合成策略。该方法的优点包括良好的官能团耐受性、温和的条件以及廉价或易于处理的原料。机理研究表明，原位形成的硫代羰基氟化物是反应中的关键中间体。
