Department of Surgical and Biomedical Sciences, University of Sassari, Sassari, Italy.
Istituto di Ricerca Genetica e Biomedica (IRGB), CNR, Cittadella Universitaria di Cagliari, Monserrato, CA, Italy.
Retina. 2020 Jul;40(7):1224-1233. doi: 10.1097/IAE.0000000000002604.
To assess the long-term evolution of treatment-naive quiescent choroidal neovascularization (CNV), in age-related macular degeneration (AMD), to identify predictive activation biomarkers.
Patients with quiescent CNV underwent a comprehensive ophthalmological examination, including fluorescein and indocyanine green angiographies, structural optical coherence tomography (OCT), and OCT angiography. Qualitative and quantitative analyses of structural OCT and OCT angiography images were performed during the study period. At the last follow-up evaluation, the enrolled eyes were divided into two groups: eyes with quiescent CNV converting to exudative AMD (eAMD) and those not progressing to eAMD.
Sixty-eight eyes of 68 patients were enrolled in the study. Mean follow-up duration was 40 ± 28 months using multimodal imaging and 22 ± 13 months using OCT angiography. On structural OCT, quiescent CNV not converting to eAMD showed a preferential growth of the pigment epithelium detachment greatest linear diameter (P = 0.009), whereas the eAMD group presented a preferential growth of the pigment epithelium detachment maximal height (P < 0.0001) during the study period. Quantitative analysis of choriocapillaris OCT angiograms confirmed the CNV area growth during follow-up (from 4.18 ± 4.77 mm at baseline to 5.10 ± 5.06 mm at the last follow-up visit; P = 0.02).
A close follow-up is recommended to early identify predictive activation biomarkers of treatment-naive quiescent CNV.
评估未经治疗的静止性脉络膜新生血管（CNV）在年龄相关性黄斑变性（AMD）中的长期演变，以确定预测激活的生物标志物。
静止性 CNV 患者接受全面眼科检查，包括荧光素和吲哚青绿血管造影、结构光学相干断层扫描（OCT）和 OCT 血管造影。在研究期间对结构 OCT 和 OCT 血管造影图像进行定性和定量分析。在最后一次随访评估时，纳入的眼睛分为两组：静止性 CNV 转化为渗出性 AMD（eAMD）的眼睛和未进展为 eAMD 的眼睛。
本研究纳入了 68 例 68 只眼。使用多模态成像的平均随访时间为 40 ± 28 个月，使用 OCT 血管造影的平均随访时间为 22 ± 13 个月。在结构 OCT 上，未转化为 eAMD 的静止性 CNV 显示色素上皮脱离最大线性直径（PED）优先增长（P = 0.009），而 eAMD 组在研究期间PED 最大高度（PEDH）优先增长（P < 0.0001）。脉络膜毛细血管 OCT 血管造影的定量分析证实了 CNV 区域在随访期间的生长（从基线时的 4.18 ± 4.77mm 增加到最后一次随访时的 5.10 ± 5.06mm；P = 0.02）。
建议密切随访，以早期识别未经治疗的静止性 CNV 的预测激活生物标志物。
