Department of Child Neurology, University of Health Sciences, Derince Training and Research Hospital, 41900 Kocaeli, Turkey.
Department of Neurosurgery, University of Health Sciences, Şişli Hamidiye Etfal Training and Research Hospital, 34371 Istanbul, Turkey.
Medicina (Kaunas). 2019 Jun 28;55(7):321. doi: 10.3390/medicina55070321.
Vitamin D deficiency and insufficiency are related with many neurological diseases such as migraine. The aim of this study was to investigate whether pediatric migraine is associated with vitamin D deficiency and the effect of vitamin D therapy on the frequency, duration, severity of migraine attacks, and Pediatric Migraine Disability Assessment (PedMIDAS).
We retrospectively examined the patients' levels of calcium, phosphorus, parathyroid hormone, alkaline phosphatase, and 25-OH vitamin D of 92 pediatric migraine patients. The patients were divided into two groups: Group 1, which had low vitamin D levels and received vitamin D therapy, and group 2, which had normal vitamin D levels and did not receive vitamin D therapy. Migraine severity measured by the visual analog scale (VAS), migraine frequency, and duration as well as scores on the PedMIDAS questionnaire were compared with regard to the 25-OH vitamin D levels. In addition, pre- and posttreatment pedMIDAS scores, VAS, migraine frequency, and duration were compared with baseline values.
A total of 34.7% patients had vitamin D insufficiency (vitamin D levels between 10 and 20 ng/mL), whereas 10.8% had vitamin D deficiency (vitamin D levels < 10 ng/mL). Migraine frequency, migraine duration, and PedMIDAS scores were significantly higher in the group 1 than group 2 ( = 0.004, = 0.008, and = 0.001). After vitamin D therapy at sixth months of supplementation, migraine duration was reported statistically significant shorter (p < 0.001) and the migraine frequency, VAS scores, and pedMIDAS scores were statistically significant lower compared with baseline values in group 1 ( < 0.001).
We found a marked correlation between pediatric migraine and vitamin D levels. Vitamin D therapy was beneficial in migraine pediatric patients.
维生素 D 缺乏和不足与许多神经疾病有关，如偏头痛。本研究旨在探讨儿童偏头痛是否与维生素 D 缺乏有关，以及维生素 D 治疗对偏头痛发作频率、持续时间、严重程度和儿科偏头痛残疾评估（PedMIDAS）的影响。
我们回顾性检查了 92 例儿童偏头痛患者的钙、磷、甲状旁腺激素、碱性磷酸酶和 25-羟维生素 D 水平。将患者分为两组：组 1 维生素 D 水平较低并接受维生素 D 治疗，组 2 维生素 D 水平正常且未接受维生素 D 治疗。使用视觉模拟量表（VAS）比较偏头痛严重程度、偏头痛频率、持续时间以及 PedMIDAS 问卷评分与 25-羟维生素 D 水平的关系。此外，还比较了治疗前后的 PedMIDAS 评分、VAS、偏头痛频率和持续时间与基线值的差异。
共有 34.7%的患者存在维生素 D 不足（10-20ng/mL），10.8%的患者存在维生素 D 缺乏（<10ng/mL）。组 1 的偏头痛频率、偏头痛持续时间和 PedMIDAS 评分均明显高于组 2（=0.004、=0.008 和=0.001）。在补充维生素 D 治疗 6 个月后，组 1 的偏头痛持续时间明显缩短（p<0.001），偏头痛频率、VAS 评分和 PedMIDAS 评分均明显低于基线值（<0.001）。
我们发现儿童偏头痛与维生素 D 水平之间存在显著相关性。维生素 D 治疗对儿童偏头痛患者有益。
