University of Navarra, Department of Preventive Medicine and Public Health, School of Medicine, Pamplona, Spain.
University of Navarra, Department of Preventive Medicine and Public Health, School of Medicine, Pamplona, Spain; CIBER Pathophysiology of Obesity and Nutrition (CIBERobn), Institute of Health Carlos III, Madrid, Spain; IDISNA Navarra's Health Research Institute, Pamplona, Spain; Department of Nutrition, Harvard TH Chan School of Public Health, Boston, MA, United States.
Eur Psychiatry. 2019 Sep;61:33-40. doi: 10.1016/j.eurpsy.2019.06.002. Epub 2019 Jun 29.
Lifestyles are involved in the pathogenesis of depression and many of these factors can be modified for the potential prevention of depression. Our aim was to assess the association between a healthy-lifestyle score, that includes some less-studied lifestyle indicators, and the risk of depression.
We followed 14,908 participants initially free of any history of depression in the "Seguimiento Universidad de Navarra" (SUN) cohort. Information was collected biennially from 1999 to December 2016. We calculated a healthy-lifestyle score (0-10 points), previously associated with cardioprotection, by giving one point to each of the following components: never smoking, physical activity (> 20 METs-h/week), Mediterranean diet adherence (≥ 4 points), healthy body mass index (≤ 22 kg/m), moderate alcohol consumption (women 0.1-5 g/d; men 0.1-10 g/d of ethanol), avoidance of binge drinking (never more than 5 alcoholic drinks in a row), low television exposure (≤ 2 h/d), short afternoon nap (≤ 30 min/day), time spent with friends (>1 h/d) and working at least 40 h/week.
During a median follow-up of 10.4 years, we observed 774 new cases of major depression among participants initially free of depression. The highest category (8-10 factors) showed a significant inverse association with a 32% relative risk reduction for depression compared to the lowest category (0-3 factors) (multivariable-adjusted hazard ratio: 0.68; 95% CI:0.49-0.95) (p for trend = 0.010).
Adopting a healthy-lifestyle was associated with a lower risk of incident depression in the SUN cohort. This index, including ten simple healthy lifestyle habits, may be useful for a more integrative approach to depression prevention.
生活方式与抑郁症的发病机制有关，其中许多因素可以通过改变来预防抑郁症。我们的目的是评估包括一些研究较少的生活方式指标在内的健康生活方式评分与抑郁症风险之间的关系。
我们对“纳瓦拉大学随访研究”（SUN）队列中最初无任何抑郁症病史的 14908 名参与者进行了随访。从 1999 年到 2016 年 12 月，每两年收集一次信息。我们通过给以下每个组成部分加 1 分来计算健康生活方式评分（0-10 分），该评分先前与心脏保护有关：从不吸烟、身体活动（>20 METs-h/周）、地中海饮食依从性（≥4 分）、健康体重指数（≤22kg/m）、适量饮酒（女性 0.1-5g/d；男性 0.1-10g/d 乙醇）、避免狂饮（从不连续超过 5 杯酒）、低电视暴露（≤2h/d）、短暂的午后小睡（≤30min/d）、与朋友相处的时间（>1h/d）和每周至少工作 40h。
在中位随访 10.4 年期间，我们观察到最初无抑郁症的参与者中有 774 例新发重度抑郁症。与最低分类（0-3 个因素）相比，最高分类（8-10 个因素）的相对风险降低了 32%，具有显著的反向关联（多变量调整后的危险比：0.68；95%CI：0.49-0.95）（趋势检验 p 值=0.010）。
在 SUN 队列中，采用健康的生活方式与较低的新发抑郁症风险相关。这个指数包括十个简单的健康生活习惯，可能对更综合的抑郁症预防方法有用。
