Huovinen P, Huovinen S, Jacoby G A
Massachusetts General Hospital, Boston 02114.
Antimicrob Agents Chemother. 1988 Jan;32(1):134-6. doi: 10.1128/AAC.32.1.134.
The nucleotide sequence of PSE-2 beta-lactamase, an enzyme that readily hydrolyzes both carbenicillin and oxacillin, has been determined. The deduced sequence of 266 amino acids contained 93 residues identical to those of OXA-2 beta-lactamase and the Ser-Thr-Phe-Lys tetrad also found in the active site of TEM-1 beta-lactamase.
已确定PSE-2β-内酰胺酶的核苷酸序列，该酶能迅速水解羧苄青霉素和苯唑西林。推导的266个氨基酸序列中有93个残基与OXA-2β-内酰胺酶相同，并且在TEM-1β-内酰胺酶活性位点中也发现了丝氨酸-苏氨酸-苯丙氨酸-赖氨酸四联体。
