Bioengineering Department, Uskudar University, Uskudar, 34662, Turkey.
Bioengineering Department, Marmara University, Kadikoy, 34722, Turkey.
Pathog Glob Health. 2023 May;117(3):219-234. doi: 10.1080/20477724.2022.2088496. Epub 2022 Jun 26.
The production of β-lactamases is a prevalent mechanism that poses serious pressure on the control of bacterial resistance. Furthermore, the unavoidable and alarming increase in the transmission of bacteria producing extended-spectrum β-lactamases complicates treatment alternatives with existing drugs and/or approaches. Class D β-lactamases, designated as OXA enzymes, are characterized by their activity specifically towards oxacillins. They are widely distributed among the ESKAPE bugs that are associated with antibiotic resistance and life-threatening hospital infections. The inadequacy of current β-lactamase inhibitors for conventional treatments of 'OXA' mediated infections confirms the necessity of new approaches. Here, the focus is on the mechanistic details of OXA-10, OXA-23, and OXA-48, commonly found in highly virulent and antibiotic-resistant pathogens , and . to describe their similarities and differences. Furthermore, this review contains a specific emphasis on structural and computational perspectives, which will be valuable to guide efforts in the design/discovery of a common single-molecule drug against ESKAPE pathogens.
β-内酰胺酶的产生是一种普遍的机制，对细菌耐药性的控制构成了严重的压力。此外，具有扩展谱β-内酰胺酶的细菌传播不可避免且令人震惊地增加，这使得现有的药物和/或方法的治疗选择变得复杂。被指定为 OXA 酶的 D 类β-内酰胺酶的特点是对氧头孢菌素具有特异性活性。它们广泛分布在与抗生素耐药性和危及生命的医院感染相关的 ESKAPE 细菌中。目前的β-内酰胺酶抑制剂对于“OXA”介导的感染的常规治疗的不足证实了新方法的必要性。在这里，重点是在机制细节上的 OXA-10、OXA-23 和 OXA-48，它们通常在高毒力和抗药性的病原体中发现，以描述它们的相似性和差异。此外，本综述特别强调了结构和计算的观点，这对于指导针对 ESKAPE 病原体的单一分子药物的设计/发现将是有价值的。
