Cancer Control and Population Sciences Program, Huntsman Cancer Institute, Salt Lake City, UT.
Department of Health, Kinesiology, and Recreation, The University of Utah, Salt Lake City, UT.
Med Sci Sports Exerc. 2019 Nov;51(11):2193-2200. doi: 10.1249/MSS.0000000000002048.
This trial aimed to demonstrate the feasibility of high-intensity interval training (HIIT) in postmenopausal, overweight/obese women at high risk of invasive breast cancer and to explore HIIT on changes in cardiorespiratory fitness (CRF), body weight, and body mass index (BMI) compared with moderate-intensity continuous training (MICT) and usual care (UC).
Forty-four women were randomized to HIIT, MICT, or UC for a 12-wk, thrice weekly, supervised exercise intervention. HIIT included a 5-min warm-up at 50%-70% HRpeak, four cycles of 4 min at 90%-100% HRpeak, followed by 3 min at 50%-70% HRpeak. MICT consisted of 41 min at 60%-70% HRpeak. Feasibility was assessed by consent, adherence, compliance, and retention rates. CRF, body weight, and BMI were measured at baseline and end of study. Repeated-measures linear mixed models were used to assess within- and between-group differences.
Average age was 63.9 ± 8.8 yr. BMI was 30.9 ± 5.7 kg·m. Participants completed 90% and 89% of HIIT and MICT workouts, respectively, with 100% compliance to the exercise prescriptions. No serious adverse events were reported. Compared with MICT and UC, HIIT exhibited improvements in change in treadmill time (101 s greater than MICT, and 125 s greater than UC, respectively, P < 0.001). Compared with UC, HIIT exhibited improvement in changes in absolute and relative V˙O2peak (a 0.15-L·min increase, P = 0.005, and a 2.3-mL·kg⋅min increase, P = 0.004). There were no significant differences between groups for body weight or BMI (P > 0.05).
HIIT is feasible, safe, and seems to promote greater improvements in CRF compared with MICT and UC in women at high risk for breast cancer.
本试验旨在证实高强度间歇训练（HIIT）应用于高侵袭性乳腺癌风险的绝经后超重/肥胖女性的可行性，并探索 HIIT 对心肺功能（CRF）、体重和体重指数（BMI）的影响，与中等强度持续训练（MICT）和常规护理（UC）进行比较。
44 名女性被随机分配到 HIIT、MICT 或 UC 组，进行为期 12 周、每周 3 次的监督运动干预。HIIT 包括 5 分钟的 50%-70%最大心率（HRpeak）热身，4 分钟的 90%-100%HRpeak 循环，随后 3 分钟的 50%-70%HRpeak。MICT 包括 60%-70%HRpeak 的 41 分钟。通过同意、依从性、顺应性和保留率评估可行性。在基线和研究结束时测量 CRF、体重和 BMI。使用重复测量线性混合模型评估组内和组间差异。
平均年龄为 63.9 ± 8.8 岁。BMI 为 30.9 ± 5.7kg·m。HIIT 和 MICT 运动的完成率分别为 90%和 89%，对运动处方的依从性为 100%。未报告严重不良事件。与 MICT 和 UC 相比，HIIT 在跑步机时间的变化上表现出改善（比 MICT 多 101s，比 UC 多 125s，P<0.001）。与 UC 相比，HIIT 表现出绝对和相对 V˙O2peak 的变化改善（增加 0.15L·min，P=0.005 和增加 2.3mL·kg·min，P=0.004）。两组间体重或 BMI 无显著差异（P>0.05）。
HIIT 是可行的、安全的，并且似乎比 MICT 和 UC 更能提高高危乳腺癌女性的 CRF。
