Department of Environmental and Preventive Medicine, Hyogo College of Medicine, Nishinomiya, Japan.
Platelets. 2020;31(2):265-267. doi: 10.1080/09537104.2019.1636022. Epub 2019 Jul 3.
Alcohol inhibits platelet function, and platelet count is often reduced in individuals with alcohol use disorder. However, the relation of habitual alcohol drinking with platelet count in a general population remains to be determined. The participants were 6508 men (30 ~ 69 years old) who had received annual health checkup examinations, and most of them (98.6%) were nondrinkers or drinkers with an average ethanol intake of less than 66 g per day. Relationships of platelet count with alcohol intake were investigated by using analysis of covariance and multivariate linear and logistic regression analyses. Platelet count was significantly correlated with age, smoking, γ-glutamyl transpeptidase, body mass index and leukocyte count, which were thus used as explanatory variables in the multivariate analyses. Mean platelet counts in light (<22 g of ethanol per day), moderate (≥22 and <44 g ethanol per day) and heavy (≥44 g ethanol per day) drinkers were not significantly different from that in nondrinkers. Odds ratios vs. nondrinkers of light, moderate and heavy drinkers for low platelet count (<15 x 10/μl) were not significantly different from the reference level. In conclusion, there is no association between habitual alcohol drinking and platelet count in a general population. Further studies using data for heavier drinkers are needed to confirm the relationship between alcohol use disorder and platelet count.
酒精会抑制血小板功能，且经常饮酒者的血小板计数通常较低。然而，习惯性饮酒与普通人群血小板计数之间的关系仍有待确定。该研究的参与者为 6508 名男性（30~69 岁），他们接受了年度健康检查，其中大多数（98.6%）为非饮酒者或平均每天乙醇摄入量低于 66 克的饮酒者。通过协方差分析、多元线性和逻辑回归分析，研究了血小板计数与饮酒量之间的关系。血小板计数与年龄、吸烟、γ-谷氨酰转肽酶、体重指数和白细胞计数显著相关，因此在多元分析中，这些因素被用作解释变量。轻度（<22 克乙醇/天）、中度（≥22 且 <44 克乙醇/天）和重度（≥44 克乙醇/天）饮酒者的平均血小板计数与不饮酒者无显著差异。与不饮酒者相比，轻度、中度和重度饮酒者血小板计数较低（<15 x 10/μl）的比值比与参考水平无显著差异。总之，在普通人群中，习惯性饮酒与血小板计数之间没有关联。需要使用更多关于重度饮酒者的数据进行进一步研究，以确定酒精使用障碍与血小板计数之间的关系。
