Technical considerations in detection of HERV-K in amyotrophic lateral sclerosis: selection of controls and the perils of qPCR.
作者信息
Garcia-Montojo Marta, Li Wenxue, Nath Avindra
机构信息
Section of Infections of the Nervous System, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
出版信息
Acta Neuropathol Commun. 2019 Jul 3;7(1):101. doi: 10.1186/s40478-019-0753-z.
Abstract
摘要
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Technical considerations in detection of HERV-K in amyotrophic lateral sclerosis: selection of controls and the perils of qPCR.肌萎缩侧索硬化症中人类内源性逆转录病毒-K检测的技术考量：对照的选择及定量聚合酶链反应的风险
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Postmortem Cortex Samples Identify Distinct Molecular Subtypes of ALS: Retrotransposon Activation, Oxidative Stress, and Activated Glia.尸检大脑皮质样本鉴定出 ALS 的不同分子亚型：逆转录转座子激活、氧化应激和激活的神经胶质细胞。
Cell Rep. 2019 Oct 29;29(5):1164-1177.e5. doi: 10.1016/j.celrep.2019.09.066.
2
Quantitative analysis of human endogenous retrovirus-K transcripts in postmortem premotor cortex fails to confirm elevated expression of HERV-K RNA in amyotrophic lateral sclerosis.对尸检前运动皮层中人内源性逆转录病毒-K 转录物的定量分析未能证实肌萎缩侧索硬化症中 HERV-K RNA 的表达升高。
Acta Neuropathol Commun. 2019 Mar 18;7(1):45. doi: 10.1186/s40478-019-0698-2.
3
Tau Activates Transposable Elements in Alzheimer's Disease.tau 蛋白激活阿尔茨海默病中的转座元件。
Cell Rep. 2018 Jun 5;23(10):2874-2880. doi: 10.1016/j.celrep.2018.05.004.
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Humoral immunity response to human endogenous retroviruses K/W differentiates between amyotrophic lateral sclerosis and other neurological diseases.体液免疫对人类内源性逆转录病毒 K/W 的反应可区分肌萎缩侧索硬化症和其他神经疾病。
Eur J Neurol. 2018 Aug;25(8):1076-e84. doi: 10.1111/ene.13648. Epub 2018 May 14.
5
Assessment of brain reference genes for RT-qPCR studies in neurodegenerative diseases.评估神经退行性疾病 RT-qPCR 研究中的脑参考基因。
Sci Rep. 2016 Nov 17;6:37116. doi: 10.1038/srep37116.
6
Human endogenous retrovirus-K contributes to motor neuron disease.人类内源性逆转录病毒-K与运动神经元疾病有关。
Sci Transl Med. 2015 Sep 30;7(307):307ra153. doi: 10.1126/scitranslmed.aac8201.
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Differential expression of HERV-K (HML-2) proviruses in cells and virions of the teratocarcinoma cell line Tera-1.人内源性逆转录病毒K（HML-2）前病毒在畸胎瘤细胞系Tera-1的细胞和病毒颗粒中的差异表达。
Viruses. 2015 Mar 4;7(3):939-68. doi: 10.3390/v7030939.
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The distribution of insertionally polymorphic endogenous retroviruses in breast cancer patients and cancer-free controls.插入多态性内源性逆转录病毒在乳腺癌患者和无癌对照中的分布。
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Prostate cancer progression correlates with increased humoral immune response to a human endogenous retrovirus GAG protein.前列腺癌的进展与针对人类内源性逆转录病毒 GAG 蛋白的体液免疫反应增强相关。
Clin Cancer Res. 2013 Nov 15;19(22):6112-25. doi: 10.1158/1078-0432.CCR-12-3580. Epub 2013 Sep 30.
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