巨噬细胞Ia和细胞杀伤活性的同时表达及其对抗抗原呈递的影响。
Simultaneous expression of Ia and cytocidal activity by macrophages, and the consequences for antigen presentation.
作者信息
Friedman A, Beller D I
机构信息
Department of Pathology, Harvard Medical School, Boston, Massachusetts.
出版信息
Immunology. 1987 Aug;61(4):435-41.
We have investigated whether the interrelationship of Ia expression and cytotoxicity by macrophages, as the two functions if expressed at the same time, might be counterproductive for T-cell development and function. We report that, under some circumstances, there is a clear dissociation of the two activities, as was demonstrated for both in vitro and in vivo conditions. However, the two functions could also be superimposed. Dissociation or superimposition was determined by (i) the nature of the inducing stimulus, and (ii) by the time-span between stimulation and evaluation. It was found that Ia and tumour killing were mainly expressed by the same macrophage population and, as a result, cytolytic activity, when associated with Ia expression, can be directed against T-cell hybridomas in an antigen-specific manner. The physiological relevance of the dissociation or superimposition of Ia expression and tumour killing by macrophages is discussed.
我们研究了巨噬细胞Ia表达与细胞毒性之间的相互关系，若这两种功能同时表达，对于T细胞的发育和功能是否会产生反作用。我们报告，在某些情况下，这两种活性存在明显的分离，体外和体内条件下均已证实。然而，这两种功能也可能叠加。分离或叠加取决于：（i）诱导刺激的性质；（ii）刺激与评估之间的时间跨度。结果发现，Ia和肿瘤杀伤主要由同一巨噬细胞群体表达，因此，与Ia表达相关的溶细胞活性可抗原特异性地针对T细胞杂交瘤。本文讨论了巨噬细胞Ia表达与肿瘤杀伤的分离或叠加的生理相关性。
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