Department of Chemical and Biomolecular Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Biomaterials. 2019 Oct;217:119292. doi: 10.1016/j.biomaterials.2019.119292. Epub 2019 Jun 21.
Neurodegenerative diseases and disorders seriously impact memory and cognition and can become life-threatening. Current medical techniques attempt to combat these detrimental effects mainly through the administration of neuromedicine. However, drug efficacy is limited by rapid dispersal of the drugs to off-target sites while the site of administration is prone to overdose. Many neuropathological conditions are accompanied by excessive reactive oxygen species (ROS) due to the inflammatory response. Accordingly, ROS-responsive drug delivery systems have emerged as a promising solution. To guide intelligent and comprehensive design of ROS-responsive drug delivery systems, this review article discusses the two following topics: (1) the biology of ROS in both healthy and diseased nervous systems and (2) recent developments in ROS-responsive, drug delivery system design. Overall, this review article would assist efforts to make better decisions about designing ROS-responsive, neural drug delivery systems, including the selection of ROS-responsive functional groups.
神经退行性疾病和障碍严重影响记忆和认知能力，并且可能危及生命。目前的医学技术主要通过神经药物来尝试对抗这些有害影响。然而，由于药物迅速扩散到非靶部位，同时给药部位容易出现药物过量，药物的疗效受到限制。许多神经病理学状况伴随着由于炎症反应而产生的过多的活性氧（ROS）。因此，ROS 响应性药物递送系统已成为一种很有前途的解决方案。为了指导 ROS 响应性药物递送系统的智能和全面设计，本文讨论了以下两个主题：（1）ROS 在健康和患病神经系统中的生物学；（2）ROS 响应性药物递送系统设计的最新进展。总的来说，本文将有助于在设计 ROS 响应性神经药物递送系统方面做出更好的决策，包括 ROS 响应性功能基团的选择。
